Impaired mitochondria of Tregs decreases OXPHOS-derived ATP in primary immune thrombocytopenia with positive plasma pathogens detected by metagenomic sequencing

Impaired mitochondria of Tregs decreases OXPHOS-derived ATP in primary immune thrombocytopenia with positive plasma pathogens detected by metagenomic sequencing

Abstract Background Primary immune thrombocytopenia (ITP) is an autoimmune disease. Some ITP patients are associated with pathogen infection undetected with conventional technologies. Investigating the changes of T cells and potential metabolic mechanism are important for better understanding of ITP...

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Bibliographic Details
Main Authors: Yanxia Zhan, Jingjing Cao, Lili Ji, Miaomiao Zhang, Qi Shen, Pengcheng Xu, Xibing Zhuang, Shanshan Qin, Fanli Hua, Lihua Sun, Feng Li, Hao Chen, Yunfeng Cheng
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Experimental Hematology & Oncology
Subjects:
Immune thrombocytopenia
Tregs (Regulatory T cells)
Glycolysis
Oxidative phosphorylation
Pathogens
Online Access:https://doi.org/10.1186/s40164-022-00304-y

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