A glutamine-based single α-helix scaffold to target globular proteins
Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.
Bibliographic Details
| Main Authors: |
Albert Escobedo,
Jonathan Piccirillo,
Juan Aranda,
Tammo Diercks,
Borja Mateos,
Carla Garcia-Cabau,
Macarena Sánchez-Navarro,
Busra Topal,
Mateusz Biesaga,
Lasse Staby,
Birthe B. Kragelund,
Jesús García,
Oscar Millet,
Modesto Orozco,
Murray Coles,
Ramon Crehuet,
Xavier Salvatella |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34793-6
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