Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma Patients
Lower-grade Gliomas anchored in eloquent areas cause varying degrees of language impairment. Except for a tumor’s features, contralesional compensation may explain these differences. Therefore, studying changes in the contralateral hemisphere can provide insights into the underlying mechanisms of la...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/18/4469 |
| _version_ | 1797490243370221568 |
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| author | Chunyao Zhou Shengyu Fang Shimeng Weng Zhong Zhang Tao Jiang Yinyan Wang Lei Wang Kai Tang |
| author_facet | Chunyao Zhou Shengyu Fang Shimeng Weng Zhong Zhang Tao Jiang Yinyan Wang Lei Wang Kai Tang |
| author_sort | Chunyao Zhou |
| collection | DOAJ |
| description | Lower-grade Gliomas anchored in eloquent areas cause varying degrees of language impairment. Except for a tumor’s features, contralesional compensation may explain these differences. Therefore, studying changes in the contralateral hemisphere can provide insights into the underlying mechanisms of language function compensation in patients with gliomas. This study included 60 patients with eloquent-area or near-eloquent-area gliomas. The participants were grouped according to the degree of language defect. T1 and diffusion tensor imaging were obtained. The contralesional cortical volume and the subcortical network were compared between groups. Patients with unimpaired language function showed elevated cortical volume in the midline areas of the frontal and temporal lobes. In subcortical networks, the group also had the highest global efficiency and shortest global path length. Ten nodes had intergroup differences in nodal efficiency, among which four nodes were in the motor area and four nodes were in the language area. Linear correlation was observed between the efficiency of the two nodes and the patient’s language function score. Functional compensation in the contralesional hemisphere may alleviate language deficits in patients with gliomas. Structural compensation mainly occurs in the contralesional midline area in the frontal and temporal lobes, and manifests as an increase in cortical volume and subcortical network efficiency. |
| first_indexed | 2024-03-10T00:29:13Z |
| format | Article |
| id | doaj.art-0ea4e199ae914559a5ea7e0db08905b2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:29:13Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0ea4e199ae914559a5ea7e0db08905b22023-11-23T15:27:49ZengMDPI AGCancers2072-66942022-09-011418446910.3390/cancers14184469Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma PatientsChunyao Zhou0Shengyu Fang1Shimeng Weng2Zhong Zhang3Tao Jiang4Yinyan Wang5Lei Wang6Kai Tang7Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaLower-grade Gliomas anchored in eloquent areas cause varying degrees of language impairment. Except for a tumor’s features, contralesional compensation may explain these differences. Therefore, studying changes in the contralateral hemisphere can provide insights into the underlying mechanisms of language function compensation in patients with gliomas. This study included 60 patients with eloquent-area or near-eloquent-area gliomas. The participants were grouped according to the degree of language defect. T1 and diffusion tensor imaging were obtained. The contralesional cortical volume and the subcortical network were compared between groups. Patients with unimpaired language function showed elevated cortical volume in the midline areas of the frontal and temporal lobes. In subcortical networks, the group also had the highest global efficiency and shortest global path length. Ten nodes had intergroup differences in nodal efficiency, among which four nodes were in the motor area and four nodes were in the language area. Linear correlation was observed between the efficiency of the two nodes and the patient’s language function score. Functional compensation in the contralesional hemisphere may alleviate language deficits in patients with gliomas. Structural compensation mainly occurs in the contralesional midline area in the frontal and temporal lobes, and manifests as an increase in cortical volume and subcortical network efficiency.https://www.mdpi.com/2072-6694/14/18/4469gliomalanguage performancesubcortical networkgraphic theoryvoxel-based morphometrydiffusion tensor image |
| spellingShingle | Chunyao Zhou Shengyu Fang Shimeng Weng Zhong Zhang Tao Jiang Yinyan Wang Lei Wang Kai Tang Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma Patients Cancers glioma language performance subcortical network graphic theory voxel-based morphometry diffusion tensor image |
| title | Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma Patients |
| title_full | Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma Patients |
| title_fullStr | Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma Patients |
| title_full_unstemmed | Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma Patients |
| title_short | Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma Patients |
| title_sort | contralesional cortical and network features associated with preoperative language deficit in glioma patients |
| topic | glioma language performance subcortical network graphic theory voxel-based morphometry diffusion tensor image |
| url | https://www.mdpi.com/2072-6694/14/18/4469 |
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