Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration
Background: Recent literature data highlights metabolic changes in amyotrophic lateral sclerosis (ALS). To explore possible early metabolic changes, we aimed to analyse the fatty acids (FA) composition of erythrocytes in newly diagnosed als patients and to see whether fatty acid levels correlate wit...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2023-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304621M.pdf |
| _version_ | 1797396364811829248 |
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| author | Minić Rajna Arsić Aleksandra Kojadinović Milica Palibrk Aleksa Đorđević Brizita Stević Zorica |
| author_facet | Minić Rajna Arsić Aleksandra Kojadinović Milica Palibrk Aleksa Đorđević Brizita Stević Zorica |
| author_sort | Minić Rajna |
| collection | DOAJ |
| description | Background: Recent literature data highlights metabolic changes in amyotrophic lateral sclerosis (ALS). To explore possible early metabolic changes, we aimed to analyse the fatty acids (FA) composition of erythrocytes in newly diagnosed als patients and to see whether fatty acid levels correlate with the ALSFRS-R score or disease duration. Methods: The severity of motor function involvement was assessed by the ALSFRS-R scale at the initial evaluation. The fatty acid profile of erythrocyte membranes was analysed by gas-liquid chromatography. The study comprised 26 clinically diagnosed als patients, with mean ALSFRS-R 38±8. The control group included 26 healthy volunteers. Results: Significantly higher levels of palmitic acid and total saturated FAs were detected in als patients. In als patients, total monounsaturated FA, palmitoleic, vaccenic, and oleic acid were also significantly increased. The levels of eicosapentaenoic acid, docosapentaenoic acid, total polyunsaturated FA (PUFA) and n-6 PUFA were significantly lower in als patients. Additionally, a-linolenic acid, the precursor of the n-3 PUFA family, was not detected in als patients. We found no significant correlation between the ALSFRS-R score and the abundance of individual FAs analysed. A moderate negative correlation was found between disease duration and DHA level, and a positive correlation was detected with MUFA. Conclusion: Experimental evidence presented may contribute to shaping a beneficial nutritional intervention. |
| first_indexed | 2024-03-09T00:50:12Z |
| format | Article |
| id | doaj.art-0ea54dac3f964a6b85ec251e8e737f9e |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-03-09T00:50:12Z |
| publishDate | 2023-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-0ea54dac3f964a6b85ec251e8e737f9e2023-12-11T17:15:36ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662023-01-0142462162910.5937/jomb0-403871452-82582304621MErythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease durationMinić Rajna0https://orcid.org/0000-0003-2941-9246Arsić Aleksandra1https://orcid.org/0000-0001-8498-9415Kojadinović Milica2https://orcid.org/0000-0001-9989-8006Palibrk Aleksa3https://orcid.org/0000-0003-4941-1444Đorđević Brizita4https://orcid.org/0000-0002-4582-0809Stević Zorica5https://orcid.org/0000-0003-4549-4553University of Belgrade, Institute for Medical Research, National Institute of Republic of Serbia, Belgrade, SerbiaUniversity of Belgrade, Institute for Medical Research, National Institute of Republic of Serbia, Belgrade, SerbiaUniversity of Belgrade, Institute for Medical Research, National Institute of Republic of Serbia, Belgrade, SerbiaUniversity of Belgrade, School of Medicine, Clinical Center of Serbia, Neurology Clinic, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Belgrade, SerbiaUniversity of Belgrade, School of Medicine, Clinical Center of Serbia, Neurology Clinic, Belgrade, SerbiaBackground: Recent literature data highlights metabolic changes in amyotrophic lateral sclerosis (ALS). To explore possible early metabolic changes, we aimed to analyse the fatty acids (FA) composition of erythrocytes in newly diagnosed als patients and to see whether fatty acid levels correlate with the ALSFRS-R score or disease duration. Methods: The severity of motor function involvement was assessed by the ALSFRS-R scale at the initial evaluation. The fatty acid profile of erythrocyte membranes was analysed by gas-liquid chromatography. The study comprised 26 clinically diagnosed als patients, with mean ALSFRS-R 38±8. The control group included 26 healthy volunteers. Results: Significantly higher levels of palmitic acid and total saturated FAs were detected in als patients. In als patients, total monounsaturated FA, palmitoleic, vaccenic, and oleic acid were also significantly increased. The levels of eicosapentaenoic acid, docosapentaenoic acid, total polyunsaturated FA (PUFA) and n-6 PUFA were significantly lower in als patients. Additionally, a-linolenic acid, the precursor of the n-3 PUFA family, was not detected in als patients. We found no significant correlation between the ALSFRS-R score and the abundance of individual FAs analysed. A moderate negative correlation was found between disease duration and DHA level, and a positive correlation was detected with MUFA. Conclusion: Experimental evidence presented may contribute to shaping a beneficial nutritional intervention.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304621M.pdfamyotrophic lateral sclerosismetabolismmonounsaturated fatty acidspolyunsaturated fatty acidssaturated fatty acids |
| spellingShingle | Minić Rajna Arsić Aleksandra Kojadinović Milica Palibrk Aleksa Đorđević Brizita Stević Zorica Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration Journal of Medical Biochemistry amyotrophic lateral sclerosis metabolism monounsaturated fatty acids polyunsaturated fatty acids saturated fatty acids |
| title | Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration |
| title_full | Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration |
| title_fullStr | Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration |
| title_full_unstemmed | Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration |
| title_short | Erythrocyte fatty acid aberrations in Amyotrophic Lateral Sclerosis: Correlation with disease duration |
| title_sort | erythrocyte fatty acid aberrations in amyotrophic lateral sclerosis correlation with disease duration |
| topic | amyotrophic lateral sclerosis metabolism monounsaturated fatty acids polyunsaturated fatty acids saturated fatty acids |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304621M.pdf |
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