Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse
The precise role of estrogen in the pathogenesis of pelvic organ prolapse (POP) is still unclear, while the results concerning the effect of selective estrogen receptor modulators on pelvic organ prolapse are contradictory. Our aim was to test whether alteration in the expression of estrogen recepto...
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| Format: | Article |
| Language: | English |
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Via Medica
2011-10-01
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| Series: | Folia Histochemica et Cytobiologica |
| Subjects: | |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/9449 |
| _version_ | 1819073580048056320 |
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| author | Marie Laure Kottler Slawomir Wolczynski Geneviève Abeguile Cyril Eboue Naama Marcus-Braun Monika Zbucka-Kretowska Peter Von Theobald |
| author_facet | Marie Laure Kottler Slawomir Wolczynski Geneviève Abeguile Cyril Eboue Naama Marcus-Braun Monika Zbucka-Kretowska Peter Von Theobald |
| author_sort | Marie Laure Kottler |
| collection | DOAJ |
| description | The precise role of estrogen in the pathogenesis of pelvic organ prolapse (POP) is still unclear, while the results concerning the effect of selective estrogen receptor modulators on pelvic organ prolapse are contradictory. Our aim was to test whether alteration in the expression of estrogen receptors in the pelvic floor of preand post-menopausal women is related to genital prolapse status. The mRNA levels of ER<i>&#945;</i> and ER<i>&#946;</i> in 60 biopsy specimens were measured. Significantly higher expression of ER<i>&#945;</i> and higher ER<i>&#945;</i>/ER<i>&#946;</i> ratio were demonstrated in post-menopausal women compared to pre-menopausal women. Higher expression of ER<i>&#945;</i> and higher ER<i>&#945;</i>/ER<i>&#946;</i> ratio were detected in all studied groups with POP, thus it did not reach significance in the post-menopausal group. Pre-menopausal and post-menopausal women presenting pelvic organ prolapse had no difference in the ER<i>&alpha;</i> expression. Our preliminary study may indicate that pelvic organ prolapse is associated with higher expression of ER<i>&#945;</i>/ER<i>&#946;</i> in the pelvic floor of both pre- and post-menopausal women; thus not reaching statistical significance in the post-menopausal women was probably due to the group&#8217;s size. We believe that the inevitable changes in the estrogen receptor expression over women&#8217;s different lifetimes may affect the risk of genital prolapse progression, and might contribute to the further search for appropriate selective estrogen receptor modulators as a treatment for women with pelvic organ prolapse. (<i>Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 521&#8211;527</i>) |
| first_indexed | 2024-12-21T17:55:52Z |
| format | Article |
| id | doaj.art-0ea660b828ae4b139c24413d41f37ace |
| institution | Directory Open Access Journal |
| issn | 0239-8508 1897-5631 |
| language | English |
| last_indexed | 2024-12-21T17:55:52Z |
| publishDate | 2011-10-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Folia Histochemica et Cytobiologica |
| spelling | doaj.art-0ea660b828ae4b139c24413d41f37ace2022-12-21T18:55:12ZengVia MedicaFolia Histochemica et Cytobiologica0239-85081897-56312011-10-0149352152710.5603/9449Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapseMarie Laure KottlerSlawomir WolczynskiGeneviève AbeguileCyril EboueNaama Marcus-BraunMonika Zbucka-KretowskaPeter Von TheobaldThe precise role of estrogen in the pathogenesis of pelvic organ prolapse (POP) is still unclear, while the results concerning the effect of selective estrogen receptor modulators on pelvic organ prolapse are contradictory. Our aim was to test whether alteration in the expression of estrogen receptors in the pelvic floor of preand post-menopausal women is related to genital prolapse status. The mRNA levels of ER<i>&#945;</i> and ER<i>&#946;</i> in 60 biopsy specimens were measured. Significantly higher expression of ER<i>&#945;</i> and higher ER<i>&#945;</i>/ER<i>&#946;</i> ratio were demonstrated in post-menopausal women compared to pre-menopausal women. Higher expression of ER<i>&#945;</i> and higher ER<i>&#945;</i>/ER<i>&#946;</i> ratio were detected in all studied groups with POP, thus it did not reach significance in the post-menopausal group. Pre-menopausal and post-menopausal women presenting pelvic organ prolapse had no difference in the ER<i>&alpha;</i> expression. Our preliminary study may indicate that pelvic organ prolapse is associated with higher expression of ER<i>&#945;</i>/ER<i>&#946;</i> in the pelvic floor of both pre- and post-menopausal women; thus not reaching statistical significance in the post-menopausal women was probably due to the group&#8217;s size. We believe that the inevitable changes in the estrogen receptor expression over women&#8217;s different lifetimes may affect the risk of genital prolapse progression, and might contribute to the further search for appropriate selective estrogen receptor modulators as a treatment for women with pelvic organ prolapse. (<i>Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 521&#8211;527</i>)http://czasopisma.viamedica.pl/fhc/article/view/9449estrogen receptormenopausepelvic organ prolapseRT-PCRSERMs |
| spellingShingle | Marie Laure Kottler Slawomir Wolczynski Geneviève Abeguile Cyril Eboue Naama Marcus-Braun Monika Zbucka-Kretowska Peter Von Theobald Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse Folia Histochemica et Cytobiologica estrogen receptor menopause pelvic organ prolapse RT-PCR SERMs |
| title | Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse |
| title_full | Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse |
| title_fullStr | Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse |
| title_full_unstemmed | Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse |
| title_short | Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse |
| title_sort | expression of estrogen receptors in the pelvic floor of pre and post menopausal women presenting pelvic organ prolapse |
| topic | estrogen receptor menopause pelvic organ prolapse RT-PCR SERMs |
| url | http://czasopisma.viamedica.pl/fhc/article/view/9449 |
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