A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis
Thromboxane (TX) and prostaglandins are metabolites of arachidonic acid, a twenty-carbon unsaturated fatty acid, and have a variety of actions that are exerted via specific receptors. Angiogenesis is defined as the formation of new blood vessels from pre-existing vascular beds and is a critical comp...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223006212 |
| _version_ | 1797822097405247488 |
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| author | Masataka Majima Kanako Hosono Yoshiya Ito Hideki Amano Yoshinao Nagashima Yasuhiro Matsuda Shin-ichi Watanabe Hironobu Nishimura |
| author_facet | Masataka Majima Kanako Hosono Yoshiya Ito Hideki Amano Yoshinao Nagashima Yasuhiro Matsuda Shin-ichi Watanabe Hironobu Nishimura |
| author_sort | Masataka Majima |
| collection | DOAJ |
| description | Thromboxane (TX) and prostaglandins are metabolites of arachidonic acid, a twenty-carbon unsaturated fatty acid, and have a variety of actions that are exerted via specific receptors. Angiogenesis is defined as the formation of new blood vessels from pre-existing vascular beds and is a critical component of pathological conditions, including inflammation and cancer. Lymphatic vessels play crucial roles in the regulation of interstitial fluid, immune surveillance, and the absorption of dietary fat from the intestine; and they are also involved in the pathogenesis of various diseases. Similar to angiogenesis, lymphangiogenesis, the formation of new lymphatic vessels, is a critical component of pathological conditions. The TP-dependent accumulation of platelets in microvessels has been reported to enhance angiogenesis under pathological conditions. Although the roles of some growth factors and cytokines in angiogenesis and lymphangiogenesis have been well characterized, accumulating evidence suggests that TX induces the production of proangiogenic and prolymphangiogenic factors through the activation of adenylate cyclase, and upregulates angiogenesis and lymphangiogenesis under disease conditions. In this review, we discuss the role of TX as a regulator of angiogenesis and lymphangiogenesis, and its emerging importance as a therapeutic target. |
| first_indexed | 2024-03-13T10:02:51Z |
| format | Article |
| id | doaj.art-0eaa485bd4704e8396247e4c5c3b5396 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T10:02:51Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-0eaa485bd4704e8396247e4c5c3b53962023-05-23T04:21:14ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-07-01163114831A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesisMasataka Majima0Kanako Hosono1Yoshiya Ito2Hideki Amano3Yoshinao Nagashima4Yasuhiro Matsuda5Shin-ichi Watanabe6Hironobu Nishimura7Department of Medical Therapeutics, Kanagawa Institute of Technology, 1030 Shimo-Ogino, Atsugi, Kanagawa 243–0292, Japan; Department of Pharmacology, Kitasato University School of Medicine and Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, 1–15-1 Kitasato, Sagamihara, Kanagawa 252–0374, Japan; Corresponding author at: Department of Medical Therapeutics, Kanagawa Institute of Technology, 1030 Shimo-Ogino, Atsugi, Kanagawa 243–0292, Japan.Department of Pharmacology, Kitasato University School of Medicine and Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, 1–15-1 Kitasato, Sagamihara, Kanagawa 252–0374, JapanDepartment of Pharmacology, Kitasato University School of Medicine and Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, 1–15-1 Kitasato, Sagamihara, Kanagawa 252–0374, JapanDepartment of Pharmacology, Kitasato University School of Medicine and Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, 1–15-1 Kitasato, Sagamihara, Kanagawa 252–0374, JapanDepartment of Medical Therapeutics, Kanagawa Institute of Technology, 1030 Shimo-Ogino, Atsugi, Kanagawa 243–0292, Japan; Tokyo Research Laboratories, Kao Corporation, 2–1-3, Bunka, Sumida-ku, Tokyo 131–8501, JapanDepartment of Life Support Engineering, Kanagawa Institute of Technology, 1030 Shimo-Ogino, Atsugi, Kanagawa 243–0292, JapanDepartment of Exercise Physiology and Health Sciences, Kanagawa Institute of Technology, 1030 Shimo-Ogino, Atsugi, Kanagawa 243–0292, JapanDepartment of Biological Information, Faculty of Health and Medical Sciences, Kanagawa Institute of Technology, 1030 Shimo-Ogino, Atsugi, Kanagawa 243–0292, JapanThromboxane (TX) and prostaglandins are metabolites of arachidonic acid, a twenty-carbon unsaturated fatty acid, and have a variety of actions that are exerted via specific receptors. Angiogenesis is defined as the formation of new blood vessels from pre-existing vascular beds and is a critical component of pathological conditions, including inflammation and cancer. Lymphatic vessels play crucial roles in the regulation of interstitial fluid, immune surveillance, and the absorption of dietary fat from the intestine; and they are also involved in the pathogenesis of various diseases. Similar to angiogenesis, lymphangiogenesis, the formation of new lymphatic vessels, is a critical component of pathological conditions. The TP-dependent accumulation of platelets in microvessels has been reported to enhance angiogenesis under pathological conditions. Although the roles of some growth factors and cytokines in angiogenesis and lymphangiogenesis have been well characterized, accumulating evidence suggests that TX induces the production of proangiogenic and prolymphangiogenic factors through the activation of adenylate cyclase, and upregulates angiogenesis and lymphangiogenesis under disease conditions. In this review, we discuss the role of TX as a regulator of angiogenesis and lymphangiogenesis, and its emerging importance as a therapeutic target.http://www.sciencedirect.com/science/article/pii/S0753332223006212ThromboxaneAngiogenesisLymphangiogenesisInflammationLymphedemaHealing |
| spellingShingle | Masataka Majima Kanako Hosono Yoshiya Ito Hideki Amano Yoshinao Nagashima Yasuhiro Matsuda Shin-ichi Watanabe Hironobu Nishimura A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis Biomedicine & Pharmacotherapy Thromboxane Angiogenesis Lymphangiogenesis Inflammation Lymphedema Healing |
| title | A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis |
| title_full | A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis |
| title_fullStr | A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis |
| title_full_unstemmed | A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis |
| title_short | A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis |
| title_sort | biologically active lipid thromboxane as a regulator of angiogenesis and lymphangiogenesis |
| topic | Thromboxane Angiogenesis Lymphangiogenesis Inflammation Lymphedema Healing |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223006212 |
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