Missing persons genetic identification
<p>This article presents identification of missing persons from badly preserved post-mortem remains using molecular genetics methods. Extremely polymorphic and individually specific genetic markers that enable the identification of missing persons are microsatellites on autosomal chromosomes,...
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2017-09-01
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| Series: | Zdravniški Vestnik |
| Subjects: | |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/2330 |
| _version_ | 1818944195638853632 |
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| author | Matija Bajželj Irena Zupanič Pajnič |
| author_facet | Matija Bajželj Irena Zupanič Pajnič |
| author_sort | Matija Bajželj |
| collection | DOAJ |
| description | <p>This article presents identification of missing persons from badly preserved post-mortem remains using molecular genetics methods. Extremely polymorphic and individually specific genetic markers that enable the identification of missing persons are microsatellites on autosomal chromosomes, microsatellites on Y chromosome and control region of mitochondrial DNA. For genetic profile comparison, biological material from post-mortem remains and reference samples have to be collected. If post-mortem remains are found shortly after the presumed death of the missing person, their personal items are used for comparison. If these are not available, (the missing person‘s) relatives could be used as reference samples or achieved tissues stored in medical institutions if biopsy for the needs of medical diagnostics was performed earlier during their life. When reference samples are not available, genetic identification is not possible. The type of biological material sampled from the deceased depends on the condition of human remains. Blood, soft tissues, nails, teeth or bones are most commonly used for genetic identification, and the time required for DNA extraction depends on the type of biological material. The most demanding and time consuming is extraction of DNA from teeth and bones, therefore we use it in cases when only skeleton is available or we cannot get a sufficient amount of DNA for genetic identification from other tissues. If the genetic profile of post-mortem reamains and a reference sample of the missing person match, the strength of genetic evidence has to be statistically evaluated and the probability of identification reported.</p> |
| first_indexed | 2024-12-20T07:39:22Z |
| format | Article |
| id | doaj.art-0eac0a53dfab4a0692d187245aa94567 |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-20T07:39:22Z |
| publishDate | 2017-09-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-0eac0a53dfab4a0692d187245aa945672022-12-21T19:48:09ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242017-09-01867-82058Missing persons genetic identificationMatija Bajželj0Irena Zupanič Pajnič1Inštitut za sodno medicino, Medicinska fakulteta, Univerza v Ljubljani, LjubljanaInštitut za sodno medicino, Medicinska fakulteta, Univerza v Ljubljani, Ljubljana<p>This article presents identification of missing persons from badly preserved post-mortem remains using molecular genetics methods. Extremely polymorphic and individually specific genetic markers that enable the identification of missing persons are microsatellites on autosomal chromosomes, microsatellites on Y chromosome and control region of mitochondrial DNA. For genetic profile comparison, biological material from post-mortem remains and reference samples have to be collected. If post-mortem remains are found shortly after the presumed death of the missing person, their personal items are used for comparison. If these are not available, (the missing person‘s) relatives could be used as reference samples or achieved tissues stored in medical institutions if biopsy for the needs of medical diagnostics was performed earlier during their life. When reference samples are not available, genetic identification is not possible. The type of biological material sampled from the deceased depends on the condition of human remains. Blood, soft tissues, nails, teeth or bones are most commonly used for genetic identification, and the time required for DNA extraction depends on the type of biological material. The most demanding and time consuming is extraction of DNA from teeth and bones, therefore we use it in cases when only skeleton is available or we cannot get a sufficient amount of DNA for genetic identification from other tissues. If the genetic profile of post-mortem reamains and a reference sample of the missing person match, the strength of genetic evidence has to be statistically evaluated and the probability of identification reported.</p>http://vestnik.szd.si/index.php/ZdravVest/article/view/2330identificationhuman remainsgenetic typingmicrosatellitesmtDNA |
| spellingShingle | Matija Bajželj Irena Zupanič Pajnič Missing persons genetic identification Zdravniški Vestnik identification human remains genetic typing microsatellites mtDNA |
| title | Missing persons genetic identification |
| title_full | Missing persons genetic identification |
| title_fullStr | Missing persons genetic identification |
| title_full_unstemmed | Missing persons genetic identification |
| title_short | Missing persons genetic identification |
| title_sort | missing persons genetic identification |
| topic | identification human remains genetic typing microsatellites mtDNA |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/2330 |
| work_keys_str_mv | AT matijabajzelj missingpersonsgeneticidentification AT irenazupanicpajnic missingpersonsgeneticidentification |