Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis
Abstract Continuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the reproducibility of CGM data remains l...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40949-1 |
| _version_ | 1797576745484812288 |
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| author | Marcos Matabuena Marcos Pazos-Couselo Manuela Alonso-Sampedro Carmen Fernández-Merino Arturo González-Quintela Francisco Gude |
| author_facet | Marcos Matabuena Marcos Pazos-Couselo Manuela Alonso-Sampedro Carmen Fernández-Merino Arturo González-Quintela Francisco Gude |
| author_sort | Marcos Matabuena |
| collection | DOAJ |
| description | Abstract Continuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the reproducibility of CGM data remains limited. The present work examines the reproducibility of the results provided by a CGM system in a random sample of a free-living adult population, from a functional data analysis approach. Functional intraclass correlation coefficients (ICCs) and their 95% confidence intervals (CI) were calculated to assess the reproducibility of CGM results in 581 individuals. 62% were females 581 participants (62% women) mean age 48 years (range 18–87) were included, 12% had previously been diagnosed with diabetes. The inter-day reproducibility of the CGM results was greater for subjects with diabetes (ICC 0.46 [CI 0.39–0.55]) than for normoglycaemic subjects (ICC 0.30 [CI 0.27–0.33]); the value for prediabetic subjects was intermediate (ICC 0.37 [CI 0.31–0.42]). For normoglycaemic subjects, inter-day reproducibility was poorer among the younger (ICC 0.26 [CI 0.21–0.30]) than the older subjects (ICC 0.39 [CI 0.32–0.45]). Inter-day reproducibility was poorest among normoglycaemic subjects, especially younger normoglycaemic subjects, suggesting the need to monitor some patient groups more often than others. |
| first_indexed | 2024-03-10T21:58:06Z |
| format | Article |
| id | doaj.art-0eacdb27c6934b918df447421cd427a5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:58:06Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0eacdb27c6934b918df447421cd427a52023-11-19T13:03:19ZengNature PortfolioScientific Reports2045-23222023-08-011311910.1038/s41598-023-40949-1Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysisMarcos Matabuena0Marcos Pazos-Couselo1Manuela Alonso-Sampedro2Carmen Fernández-Merino3Arturo González-Quintela4Francisco Gude5 Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS) Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS) Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS) Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS) Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS) Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS)Abstract Continuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the reproducibility of CGM data remains limited. The present work examines the reproducibility of the results provided by a CGM system in a random sample of a free-living adult population, from a functional data analysis approach. Functional intraclass correlation coefficients (ICCs) and their 95% confidence intervals (CI) were calculated to assess the reproducibility of CGM results in 581 individuals. 62% were females 581 participants (62% women) mean age 48 years (range 18–87) were included, 12% had previously been diagnosed with diabetes. The inter-day reproducibility of the CGM results was greater for subjects with diabetes (ICC 0.46 [CI 0.39–0.55]) than for normoglycaemic subjects (ICC 0.30 [CI 0.27–0.33]); the value for prediabetic subjects was intermediate (ICC 0.37 [CI 0.31–0.42]). For normoglycaemic subjects, inter-day reproducibility was poorer among the younger (ICC 0.26 [CI 0.21–0.30]) than the older subjects (ICC 0.39 [CI 0.32–0.45]). Inter-day reproducibility was poorest among normoglycaemic subjects, especially younger normoglycaemic subjects, suggesting the need to monitor some patient groups more often than others.https://doi.org/10.1038/s41598-023-40949-1 |
| spellingShingle | Marcos Matabuena Marcos Pazos-Couselo Manuela Alonso-Sampedro Carmen Fernández-Merino Arturo González-Quintela Francisco Gude Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis Scientific Reports |
| title | Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis |
| title_full | Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis |
| title_fullStr | Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis |
| title_full_unstemmed | Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis |
| title_short | Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis |
| title_sort | reproducibility of continuous glucose monitoring results under real life conditions in an adult population a functional data analysis |
| url | https://doi.org/10.1038/s41598-023-40949-1 |
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