Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing
The skin, acting as the outer protection of the human body, is most vulnerable to injury. Wound healing can often be impaired, leading to chronic, hard-to-heal wounds. For this reason, searching for the most effective dressings that can significantly enhance the wound healing process is necessary. I...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/12/1852 |
| _version_ | 1797461193634349056 |
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| author | Łukasz Mazurek Mateusz Szudzik Mateusz Rybka Marek Konop |
| author_facet | Łukasz Mazurek Mateusz Szudzik Mateusz Rybka Marek Konop |
| author_sort | Łukasz Mazurek |
| collection | DOAJ |
| description | The skin, acting as the outer protection of the human body, is most vulnerable to injury. Wound healing can often be impaired, leading to chronic, hard-to-heal wounds. For this reason, searching for the most effective dressings that can significantly enhance the wound healing process is necessary. In this regard, silk fibroin, a protein derived from silk fibres that has excellent properties, is noteworthy. Silk fibroin is highly biocompatible and biodegradable. It can easily make various dressings, which can be loaded with additional substances to improve healing. Dressings based on silk fibroin have anti-inflammatory, pro-angiogenic properties and significantly accelerate skin wound healing, even compared to commercially available wound dressings. Animal studies confirm the beneficial influence of silk fibroin in wound healing. Clinical research focusing on fibroin dressings is also promising. These properties make silk fibroin a remarkable natural material for creating innovative, simple, and effective dressings for skin wound healing. In this review, we summarise the application of silk fibroin biomaterials as wound dressings in full-thickness, burn, and diabetic wounds in preclinical and clinical settings. |
| first_indexed | 2024-03-09T17:15:55Z |
| format | Article |
| id | doaj.art-0eb021811f3143079e6e4e64565d78a0 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T17:15:55Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0eb021811f3143079e6e4e64565d78a02023-11-24T13:34:29ZengMDPI AGBiomolecules2218-273X2022-12-011212185210.3390/biom12121852Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound HealingŁukasz Mazurek0Mateusz Szudzik1Mateusz Rybka2Marek Konop3Department of Experimental Physiology and Pathophysiology, Laboratory of Center for Preclinical Research, Medical University of Warsaw, 02-106 Warsaw, PolandDepartment of Experimental Physiology and Pathophysiology, Laboratory of Center for Preclinical Research, Medical University of Warsaw, 02-106 Warsaw, PolandDepartment of Experimental Physiology and Pathophysiology, Laboratory of Center for Preclinical Research, Medical University of Warsaw, 02-106 Warsaw, PolandDepartment of Experimental Physiology and Pathophysiology, Laboratory of Center for Preclinical Research, Medical University of Warsaw, 02-106 Warsaw, PolandThe skin, acting as the outer protection of the human body, is most vulnerable to injury. Wound healing can often be impaired, leading to chronic, hard-to-heal wounds. For this reason, searching for the most effective dressings that can significantly enhance the wound healing process is necessary. In this regard, silk fibroin, a protein derived from silk fibres that has excellent properties, is noteworthy. Silk fibroin is highly biocompatible and biodegradable. It can easily make various dressings, which can be loaded with additional substances to improve healing. Dressings based on silk fibroin have anti-inflammatory, pro-angiogenic properties and significantly accelerate skin wound healing, even compared to commercially available wound dressings. Animal studies confirm the beneficial influence of silk fibroin in wound healing. Clinical research focusing on fibroin dressings is also promising. These properties make silk fibroin a remarkable natural material for creating innovative, simple, and effective dressings for skin wound healing. In this review, we summarise the application of silk fibroin biomaterials as wound dressings in full-thickness, burn, and diabetic wounds in preclinical and clinical settings.https://www.mdpi.com/2218-273X/12/12/1852silk fibroinsilk biomaterialswound healingskin woundsburn woundsdiabetic wounds |
| spellingShingle | Łukasz Mazurek Mateusz Szudzik Mateusz Rybka Marek Konop Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing Biomolecules silk fibroin silk biomaterials wound healing skin wounds burn wounds diabetic wounds |
| title | Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing |
| title_full | Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing |
| title_fullStr | Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing |
| title_full_unstemmed | Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing |
| title_short | Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing |
| title_sort | silk fibroin biomaterials and their beneficial role in skin wound healing |
| topic | silk fibroin silk biomaterials wound healing skin wounds burn wounds diabetic wounds |
| url | https://www.mdpi.com/2218-273X/12/12/1852 |
| work_keys_str_mv | AT łukaszmazurek silkfibroinbiomaterialsandtheirbeneficialroleinskinwoundhealing AT mateuszszudzik silkfibroinbiomaterialsandtheirbeneficialroleinskinwoundhealing AT mateuszrybka silkfibroinbiomaterialsandtheirbeneficialroleinskinwoundhealing AT marekkonop silkfibroinbiomaterialsandtheirbeneficialroleinskinwoundhealing |