Treatment of Degree II Furcation Defects Using Autogenous Grafts with and without Alendronate - A Split Mouth Clinical Study
Aim: This study was conducted to evaluate the efficacy of the combination therapy i.e. inverted periosteal graft (IPG) with autogenous bone used alone and in conjunction with an osteoclast inhibitor - 1% alendronate (ALN) sodium gel, in the treatment of mandibular buccal degree II furcation defects....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Advances in Human Biology |
| Subjects: | |
| Online Access: | http://www.aihbonline.com/article.asp?issn=2321-8568;year=2014;volume=4;issue=3;spage=10;epage=20;aulast=Kumar;type=0 |
| Summary: | Aim: This study was conducted to evaluate the efficacy of the combination therapy i.e. inverted periosteal graft (IPG) with autogenous bone used alone and in conjunction with an osteoclast inhibitor - 1% alendronate (ALN) sodium gel, in the treatment of mandibular buccal degree II furcation defects.
Materials and Method: A total of 28 buccal degree II furcation defects in 14 patients were selected and randomly divided into Group A and Group B. Experimental sites in Group A were treated using inverted periosteal graft and autogenous bone mixed with 1% alendronate gel and experimental sites in Group B were treated with inverted periosteal graft and autogenous bone only.
Results: Both the experimental groups showed significant reduction in probing pocket depth, gain in clinical attachment level and mean percentage of horizontal defect fill (41.82% vs 49.09%) at 6 months. Experimental sites in group B showed a significant loss in mean vertical defect height compared to experimental group A (1.52% Vs -1.59%).
Conclusion: It can be suggested that bisphosphonates such as alendronate sodium have the potential to inhibit the surgery induced bone loss. |
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| ISSN: | 2321-8568 2348-4691 |