Pharmacodynamics of Doripenem Alone and in Combination with Relebactam in an In Vitro Hollow-Fiber Dynamic Model: Emergence of Resistance of Carbapenemase-Producing <i>Klebsiella pneumoniae</i> and the Inoculum Effect

Pharmacodynamics of Doripenem Alone and in Combination with Relebactam in an In Vitro Hollow-Fiber Dynamic Model: Emergence of Resistance of Carbapenemase-Producing <i>Klebsiella pneumoniae</i> and the Inoculum Effect

The emergence of bacteria resistant to beta-lactam/beta-lactamase inhibitor combinations is insufficiently studied, wherein the role of the inoculum effect (IE) in decreased efficacy is unclear. To address these issues, 5-day treatments with doripenem and doripenem/relebactam combination at differen...

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Bibliographic Details
Main Authors: Elena N. Strukova, Maria V. Golikova, Svetlana A. Dovzhenko, Mikhail B. Kobrin, Stephen H. Zinner
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Antibiotics
Subjects:
antibiotic resistance
inoculum effect
in vitro hollow-fiber dynamic model
beta-lactams
beta-lactamase inhibitors
doripenem
Online Access:https://www.mdpi.com/2079-6382/12/12/1705

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