Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with Psoriasis
The systemic inflammatory syndrome concept is one of the foundations that stand at the basis of revolutionary modern and future therapies, based on the in-depth understanding of the delicate mechanisms that govern the collaboration between the systems and organs of the human body and, at the same ti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/5198 |
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| author | Daniel Octavian Costache Oana Feroiu Adelina Ghilencea Mihaela Georgescu Ana Căruntu Constantin Căruntu Sorin George Țiplica Mariana Jinga Raluca Simona Costache |
| author_facet | Daniel Octavian Costache Oana Feroiu Adelina Ghilencea Mihaela Georgescu Ana Căruntu Constantin Căruntu Sorin George Țiplica Mariana Jinga Raluca Simona Costache |
| author_sort | Daniel Octavian Costache |
| collection | DOAJ |
| description | The systemic inflammatory syndrome concept is one of the foundations that stand at the basis of revolutionary modern and future therapies, based on the in-depth understanding of the delicate mechanisms that govern the collaboration between the systems and organs of the human body and, at the same time, the fine balance that ensures a reproach-free operation. An interesting concept that we propose is that of the environment-inadequacy status, a concept that non-specifically incorporates all the situations of the organism’s response disorders in the face of imprecisely defined situations of the environment. The correlation between these two concepts will define the future of modern medicine, along with the gene-adjustment mechanisms. Psoriasis is a clear example of an inadequate body response as a result of exposure to as of yet undefined triggers with an excessive systemic inflammatory reaction and hitherto insufficiently controllable. Modern biological therapies, such as TNF-α, IL-12 family, and IL-17 inhibitors, are intended to profoundly reshape the cytokine configuration of patients with inflammatory diseases such as psoriasis, with tremendous success in disease control. Yet, because of the important roles of cytokines in cancer promotion and control, concern was raised about the fact that the use of biologicals may alter immune surveillance and promote cancer progression. Both theoretical and practical data nevertheless showed that the treatment-induced control of cytokines may be beneficial for reducing the inflammatory milieu that promotes cancer and such have a beneficial role in maintaining health. We briefly present the intricate roles of those cytokine families on cancer control, with some debates on if their inhibition might or might not promote additional tumoral development. |
| first_indexed | 2024-03-10T04:02:59Z |
| format | Article |
| id | doaj.art-0eb1e8a1fa634af6bc79cb8135254cce |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:02:59Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0eb1e8a1fa634af6bc79cb8135254cce2023-11-23T08:28:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-01239519810.3390/ijms23095198Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with PsoriasisDaniel Octavian Costache0Oana Feroiu1Adelina Ghilencea2Mihaela Georgescu3Ana Căruntu4Constantin Căruntu5Sorin George Țiplica6Mariana Jinga7Raluca Simona Costache82nd Dermatology Discipline, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDermatology Department, Carol Davila University Central Emergency Military Hospital, 010242 Bucharest, RomaniaDermatology Department, Carol Davila University Central Emergency Military Hospital, 010242 Bucharest, RomaniaDermatology Department, Carol Davila University Central Emergency Military Hospital, 010242 Bucharest, RomaniaFaculty of Medicine, Titu Maiorescu University, 040441 Bucharest, RomaniaPhysiology Discipline, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania2nd Dermatology Discipline, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaInternal Medicine and Gastroenterology Discipline, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaInternal Medicine and Gastroenterology Discipline, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaThe systemic inflammatory syndrome concept is one of the foundations that stand at the basis of revolutionary modern and future therapies, based on the in-depth understanding of the delicate mechanisms that govern the collaboration between the systems and organs of the human body and, at the same time, the fine balance that ensures a reproach-free operation. An interesting concept that we propose is that of the environment-inadequacy status, a concept that non-specifically incorporates all the situations of the organism’s response disorders in the face of imprecisely defined situations of the environment. The correlation between these two concepts will define the future of modern medicine, along with the gene-adjustment mechanisms. Psoriasis is a clear example of an inadequate body response as a result of exposure to as of yet undefined triggers with an excessive systemic inflammatory reaction and hitherto insufficiently controllable. Modern biological therapies, such as TNF-α, IL-12 family, and IL-17 inhibitors, are intended to profoundly reshape the cytokine configuration of patients with inflammatory diseases such as psoriasis, with tremendous success in disease control. Yet, because of the important roles of cytokines in cancer promotion and control, concern was raised about the fact that the use of biologicals may alter immune surveillance and promote cancer progression. Both theoretical and practical data nevertheless showed that the treatment-induced control of cytokines may be beneficial for reducing the inflammatory milieu that promotes cancer and such have a beneficial role in maintaining health. We briefly present the intricate roles of those cytokine families on cancer control, with some debates on if their inhibition might or might not promote additional tumoral development.https://www.mdpi.com/1422-0067/23/9/5198systemic inflammatory syndromepsoriasiscancerenvironment-inadequacy statusbiologic therapy |
| spellingShingle | Daniel Octavian Costache Oana Feroiu Adelina Ghilencea Mihaela Georgescu Ana Căruntu Constantin Căruntu Sorin George Țiplica Mariana Jinga Raluca Simona Costache Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with Psoriasis International Journal of Molecular Sciences systemic inflammatory syndrome psoriasis cancer environment-inadequacy status biologic therapy |
| title | Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with Psoriasis |
| title_full | Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with Psoriasis |
| title_fullStr | Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with Psoriasis |
| title_full_unstemmed | Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with Psoriasis |
| title_short | Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with Psoriasis |
| title_sort | skin inflammation modulation via tnf α il 17 and il 12 family inhibitors therapy and cancer control in patients with psoriasis |
| topic | systemic inflammatory syndrome psoriasis cancer environment-inadequacy status biologic therapy |
| url | https://www.mdpi.com/1422-0067/23/9/5198 |
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