Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis
Treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is a current problem worldwide. Currently, special attention is paid to the possibility of using new high-cost chemotherapy regimens in the treatment of MDR/XDR-TB. Numerous studies have shown that, from a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IRBIS LLC
2021-07-01
|
| Series: | Фармакоэкономика |
| Subjects: | |
| Online Access: | https://www.pharmacoeconomics.ru/jour/article/view/502 |
| _version_ | 1797878849698004992 |
|---|---|
| author | N. Yu. Nikolenko D. А. Kudlay N. P. Doktorova |
| author_facet | N. Yu. Nikolenko D. А. Kudlay N. P. Doktorova |
| author_sort | N. Yu. Nikolenko |
| collection | DOAJ |
| description | Treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is a current problem worldwide. Currently, special attention is paid to the possibility of using new high-cost chemotherapy regimens in the treatment of MDR/XDR-TB. Numerous studies have shown that, from a clinical point of view, the effectiveness of MDR/XDR-TB therapy increases with the inclusion of bedaquiline, delamanid, linezolid, fluoroquinolones (moxifloxacin, levofloxacin), and pretomanid. At the same time, there is an assumption that the use of new and repurposed anti-tuberculosis drugs (ATDs) may be associated with an increase in overall costs. This paper demonstrates the potential of pharmacoepidemiology and pharmacoeconomics to evaluate the widespread introduction of new anti-tuberculosis drugs (ATDs), taking into account all the typical features of MDR/XDR-TB therapy. The authors analyzed studies of pharmacoeconomic feasibility of using expensive drugs in treatment regimens of pulmonary tuberculosis patients with MDR/XDR pathogen. It was shown that the use of chemotherapy regimens containing new high-cost and highly effective drugs (moxifloxacin, linizolid, and bedaquiline) in rational combinations with other drugs of the basic and reserve series, selected concerning drug resistance of the pathogen, is associated with a significant economic effect. From the applicability of pharmacoeconomic analysis point of view, the introduction of short-term MDR-TB treatment regimens is also a promising direction in phthisiology. The key link to achieve effective MDR/XDR-TB treatment is the use of new drugs. Considering the specificity of pharmacoeconomic analysis in phthisiology and results of existing clinical and economic studies, the authors have formed recommendations aimed at a more complete realization of pharmacoeconomic analysis potential in MDR- and XDR-TB treatment. |
| first_indexed | 2024-04-10T02:39:41Z |
| format | Article |
| id | doaj.art-0eb1eba2b6a74a90939949c0e61fd5fa |
| institution | Directory Open Access Journal |
| issn | 2070-4909 2070-4933 |
| language | Russian |
| last_indexed | 2024-04-10T02:39:41Z |
| publishDate | 2021-07-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Фармакоэкономика |
| spelling | doaj.art-0eb1eba2b6a74a90939949c0e61fd5fa2023-03-13T07:48:17ZrusIRBIS LLCФармакоэкономика2070-49092070-49332021-07-0114210.17749/2070-4909/farmakoekonomika.2021.089335Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosisN. Yu. Nikolenko0D. А. Kudlay1N. P. Doktorova2Moscow Scientific and Practical Center for Tuberculosis ControlSechenov University; State Research Center “Institute of Immunology”; Federal Medical and Biological Agency of RussiaNational Research Medical Center for Phthisiopulmonology and Infectious DiseasesTreatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is a current problem worldwide. Currently, special attention is paid to the possibility of using new high-cost chemotherapy regimens in the treatment of MDR/XDR-TB. Numerous studies have shown that, from a clinical point of view, the effectiveness of MDR/XDR-TB therapy increases with the inclusion of bedaquiline, delamanid, linezolid, fluoroquinolones (moxifloxacin, levofloxacin), and pretomanid. At the same time, there is an assumption that the use of new and repurposed anti-tuberculosis drugs (ATDs) may be associated with an increase in overall costs. This paper demonstrates the potential of pharmacoepidemiology and pharmacoeconomics to evaluate the widespread introduction of new anti-tuberculosis drugs (ATDs), taking into account all the typical features of MDR/XDR-TB therapy. The authors analyzed studies of pharmacoeconomic feasibility of using expensive drugs in treatment regimens of pulmonary tuberculosis patients with MDR/XDR pathogen. It was shown that the use of chemotherapy regimens containing new high-cost and highly effective drugs (moxifloxacin, linizolid, and bedaquiline) in rational combinations with other drugs of the basic and reserve series, selected concerning drug resistance of the pathogen, is associated with a significant economic effect. From the applicability of pharmacoeconomic analysis point of view, the introduction of short-term MDR-TB treatment regimens is also a promising direction in phthisiology. The key link to achieve effective MDR/XDR-TB treatment is the use of new drugs. Considering the specificity of pharmacoeconomic analysis in phthisiology and results of existing clinical and economic studies, the authors have formed recommendations aimed at a more complete realization of pharmacoeconomic analysis potential in MDR- and XDR-TB treatment.https://www.pharmacoeconomics.ru/jour/article/view/502pharmacoeconomicspharmacoepidemiologytuberculosismultidrug resistanceextensive drug-resistanсeanti-tuberculosis drugs |
| spellingShingle | N. Yu. Nikolenko D. А. Kudlay N. P. Doktorova Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis Фармакоэкономика pharmacoeconomics pharmacoepidemiology tuberculosis multidrug resistance extensive drug-resistanсe anti-tuberculosis drugs |
| title | Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis |
| title_full | Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis |
| title_fullStr | Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis |
| title_full_unstemmed | Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis |
| title_short | Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis |
| title_sort | pharmacoepidemiology and pharmacoeconomics of multidrug and extensively drug resistant tuberculosis |
| topic | pharmacoeconomics pharmacoepidemiology tuberculosis multidrug resistance extensive drug-resistanсe anti-tuberculosis drugs |
| url | https://www.pharmacoeconomics.ru/jour/article/view/502 |
| work_keys_str_mv | AT nyunikolenko pharmacoepidemiologyandpharmacoeconomicsofmultidrugandextensivelydrugresistanttuberculosis AT dakudlay pharmacoepidemiologyandpharmacoeconomicsofmultidrugandextensivelydrugresistanttuberculosis AT npdoktorova pharmacoepidemiologyandpharmacoeconomicsofmultidrugandextensivelydrugresistanttuberculosis |