The Role of Hypoxia in Glioblastoma Invasion
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patient’s median survival rate ranging from 15 to 17 months. The current treatment for GBM involves tumor resection surgery based on MRI image analysis, followed by radi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/6/4/45 |
| _version_ | 1797763054627192832 |
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| author | Ana Rita Monteiro Richard Hill Geoffrey J. Pilkington Patrícia A. Madureira |
| author_facet | Ana Rita Monteiro Richard Hill Geoffrey J. Pilkington Patrícia A. Madureira |
| author_sort | Ana Rita Monteiro |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patient’s median survival rate ranging from 15 to 17 months. The current treatment for GBM involves tumor resection surgery based on MRI image analysis, followed by radiotherapy and treatment with temozolomide. However, the gradual development of tumor resistance to temozolomide is frequent in GBM patients leading to subsequent tumor regrowth/relapse. For this reason, the development of more effective therapeutic approaches for GBM is of critical importance. Low tumor oxygenation, also known as hypoxia, constitutes a major concern for GBM patients, since it promotes cancer cell spreading (invasion) into the healthy brain tissue in order to evade this adverse microenvironment. Tumor invasion not only constitutes a major obstacle to surgery, radiotherapy, and chemotherapy, but it is also the main cause of death in GBM patients. Understanding how hypoxia triggers the GBM cells to become invasive is paramount to developing novel and more effective therapies against this devastating disease. In this review, we will present a comprehensive examination of the available literature focused on investigating how GBM hypoxia triggers an invasive cancer cell phenotype and the role of these invasive proteins in GBM progression. |
| first_indexed | 2024-03-12T19:36:06Z |
| format | Article |
| id | doaj.art-0eb37bdf00ff42dfb03917172d4c32bd |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:36:06Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0eb37bdf00ff42dfb03917172d4c32bd2023-08-02T04:08:27ZengMDPI AGCells2073-44092017-11-01644510.3390/cells6040045cells6040045The Role of Hypoxia in Glioblastoma InvasionAna Rita Monteiro0Richard Hill1Geoffrey J. Pilkington2Patrícia A. Madureira3Centre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Building 8, Room 3.4, 8005-139 Faro, PortugalBrain Tumour Research Centre of Excellence, Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth PO1 2DT, UKBrain Tumour Research Centre of Excellence, Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth PO1 2DT, UKCentre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Building 8, Room 3.4, 8005-139 Faro, PortugalGlioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patient’s median survival rate ranging from 15 to 17 months. The current treatment for GBM involves tumor resection surgery based on MRI image analysis, followed by radiotherapy and treatment with temozolomide. However, the gradual development of tumor resistance to temozolomide is frequent in GBM patients leading to subsequent tumor regrowth/relapse. For this reason, the development of more effective therapeutic approaches for GBM is of critical importance. Low tumor oxygenation, also known as hypoxia, constitutes a major concern for GBM patients, since it promotes cancer cell spreading (invasion) into the healthy brain tissue in order to evade this adverse microenvironment. Tumor invasion not only constitutes a major obstacle to surgery, radiotherapy, and chemotherapy, but it is also the main cause of death in GBM patients. Understanding how hypoxia triggers the GBM cells to become invasive is paramount to developing novel and more effective therapies against this devastating disease. In this review, we will present a comprehensive examination of the available literature focused on investigating how GBM hypoxia triggers an invasive cancer cell phenotype and the role of these invasive proteins in GBM progression.https://www.mdpi.com/2073-4409/6/4/45GBMhypoxiaHIFinvasionchemotherapy |
| spellingShingle | Ana Rita Monteiro Richard Hill Geoffrey J. Pilkington Patrícia A. Madureira The Role of Hypoxia in Glioblastoma Invasion Cells GBM hypoxia HIF invasion chemotherapy |
| title | The Role of Hypoxia in Glioblastoma Invasion |
| title_full | The Role of Hypoxia in Glioblastoma Invasion |
| title_fullStr | The Role of Hypoxia in Glioblastoma Invasion |
| title_full_unstemmed | The Role of Hypoxia in Glioblastoma Invasion |
| title_short | The Role of Hypoxia in Glioblastoma Invasion |
| title_sort | role of hypoxia in glioblastoma invasion |
| topic | GBM hypoxia HIF invasion chemotherapy |
| url | https://www.mdpi.com/2073-4409/6/4/45 |
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