Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population
Abstract Background Physiological glycated hemoglobin (HbA1c) values in each trimester are not well defined. This study aimed to determine trimester-specific reference intervals for HbA1c levels in non-diabetic pregnant women in China. Methods In this cross-sectional study, 5,042 Chinese pregnant wo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-023-05980-0 |
| _version_ | 1797555783206961152 |
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| author | Yuguo Deng Danling Cheng Guilian Liao Xiaoyu Tan Jinying Yang |
| author_facet | Yuguo Deng Danling Cheng Guilian Liao Xiaoyu Tan Jinying Yang |
| author_sort | Yuguo Deng |
| collection | DOAJ |
| description | Abstract Background Physiological glycated hemoglobin (HbA1c) values in each trimester are not well defined. This study aimed to determine trimester-specific reference intervals for HbA1c levels in non-diabetic pregnant women in China. Methods In this cross-sectional study, 5,042 Chinese pregnant women from 6 to 41 weeks of gestation were screened. An inclusion of 4,134 non-diabetic women was made to determine the reference intervals, they were divided into three trimesters: trimester 1 (T1), 6 weeks to 13 weeks + 6 days, trimester 2 (T2), 14 weeks to 27 weeks + 6 days, and trimester 3 (T3), 28 weeks to 41 weeks + 6 days. A total of 4,134 women (T1 n = 760, T2 n = 1,953, and T3 n = 1,421) provided blood samples which were analyzed for HbA1c concentrations. HbA1c was measured using high-performance liquid chromatography. The median and percentile (2.5th to 97.5th) for the HbA1c reference intervals were calculated for each trimester. Results In total, 8,732 HbA1c measurements were taken. Reference intervals for HbA1c expressed as median and percentile (2.5th to 97.5th) for each trimester were: T1: 4.7 (4.0–5.5%), T2: 4.5 (3.9–5.3%), and T3: 4.8 (4.1–5.7%) respectively. The HbA1c levels were significantly lower in the second trimester compared to those in the first trimester (p < 0.0001), and higher in the third trimester compared to the second trimester (p < 0.0001). Conclusions The reference intervals for HbA1c levels were 3.9–5.7% with upper limits of 5.5% in the first trimester, 5.3% in the second trimester, and 5.7% in the third trimester. These findings highlight the importance of considering trimester-specific reference intervals for HbA1c in non-diabetic pregnant women to promote maternal and fetal health. |
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| format | Article |
| id | doaj.art-0eb4d92e48c7463fb4bcfe166f1cb2e4 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-10T16:53:33Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-0eb4d92e48c7463fb4bcfe166f1cb2e42023-11-20T11:13:38ZengBMCBMC Pregnancy and Childbirth1471-23932023-09-012311710.1186/s12884-023-05980-0Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese populationYuguo Deng0Danling Cheng1Guilian Liao2Xiaoyu Tan3Jinying Yang4Department of Obstetrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College)Department of Obstetrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College)Department of Obstetrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College)Department of Obstetrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College)Department of Obstetrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College)Abstract Background Physiological glycated hemoglobin (HbA1c) values in each trimester are not well defined. This study aimed to determine trimester-specific reference intervals for HbA1c levels in non-diabetic pregnant women in China. Methods In this cross-sectional study, 5,042 Chinese pregnant women from 6 to 41 weeks of gestation were screened. An inclusion of 4,134 non-diabetic women was made to determine the reference intervals, they were divided into three trimesters: trimester 1 (T1), 6 weeks to 13 weeks + 6 days, trimester 2 (T2), 14 weeks to 27 weeks + 6 days, and trimester 3 (T3), 28 weeks to 41 weeks + 6 days. A total of 4,134 women (T1 n = 760, T2 n = 1,953, and T3 n = 1,421) provided blood samples which were analyzed for HbA1c concentrations. HbA1c was measured using high-performance liquid chromatography. The median and percentile (2.5th to 97.5th) for the HbA1c reference intervals were calculated for each trimester. Results In total, 8,732 HbA1c measurements were taken. Reference intervals for HbA1c expressed as median and percentile (2.5th to 97.5th) for each trimester were: T1: 4.7 (4.0–5.5%), T2: 4.5 (3.9–5.3%), and T3: 4.8 (4.1–5.7%) respectively. The HbA1c levels were significantly lower in the second trimester compared to those in the first trimester (p < 0.0001), and higher in the third trimester compared to the second trimester (p < 0.0001). Conclusions The reference intervals for HbA1c levels were 3.9–5.7% with upper limits of 5.5% in the first trimester, 5.3% in the second trimester, and 5.7% in the third trimester. These findings highlight the importance of considering trimester-specific reference intervals for HbA1c in non-diabetic pregnant women to promote maternal and fetal health.https://doi.org/10.1186/s12884-023-05980-0Glycated hemoglobinNon-diabeticPregnancyReference intervals |
| spellingShingle | Yuguo Deng Danling Cheng Guilian Liao Xiaoyu Tan Jinying Yang Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population BMC Pregnancy and Childbirth Glycated hemoglobin Non-diabetic Pregnancy Reference intervals |
| title | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
| title_full | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
| title_fullStr | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
| title_full_unstemmed | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
| title_short | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
| title_sort | trimester specific reference intervals for hemoglobin a1c in non diabetic pregnancy in a chinese population |
| topic | Glycated hemoglobin Non-diabetic Pregnancy Reference intervals |
| url | https://doi.org/10.1186/s12884-023-05980-0 |
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