Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79

Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79

Fluorescence resonance energy transfer (FRET)-based sensors for 3′–5′cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) allow real-time imaging of cAMP levels and kinase activity in intact cells with high spatiotemporal resolution. The development of FRET-...

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Bibliographic Details
Main Authors: Nshunge Musheshe, Miguel J. Lobo, Martina Schmidt, Manuela Zaccolo
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Sensors
Subjects:
fluorescence resonance energy transfer (FRET)
AKAP79
cAMP
protein kinase A (PKA)
phosphatases
adrenergic signaling
real-time imaging
Online Access:http://www.mdpi.com/1424-8220/18/7/2164

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