Synthesis, radiolabeling, and evaluation of a (4-quinolinoyl)glycyl-2-cyanopyrrolidine analogue for fibroblast activation protein (FAP) PET imaging

Synthesis, radiolabeling, and evaluation of a (4-quinolinoyl)glycyl-2-cyanopyrrolidine analogue for fibroblast activation protein (FAP) PET imaging

Fibroblast activation protein (FAP) is regarded as a promising target for the diagnosis and treatment of tumors as it was overexpressed in cancer-associated fibroblasts. FAP inhibitors bearing a quinoline scaffold have been proven to show high affinity against FAP in vitro and in vivo, and the scaff...

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Bibliographic Details
Main Authors: Ni Zhang, Fei Pan, Lili Pan, Wei Diao, Feijing Su, Rui Huang, Bo Yang, Yunchun Li, Zhongzhi Qi, Wenjie Zhang, Xiaoai Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
FAP
18F-labeled FAPI
biodistribution
PET/CT imaging
blood–brain barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1167329/full

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