Anti-Glycoprotein G Antibodies of Herpes Simplex Virus 2 Contribute to Complete Protection after Vaccination in Mice and Induce Antibody-Dependent Cellular Cytotoxicity and Complement-Mediated Cytolysis

Anti-Glycoprotein G Antibodies of Herpes Simplex Virus 2 Contribute to Complete Protection after Vaccination in Mice and Induce Antibody-Dependent Cellular Cytotoxicity and Complement-Mediated Cytolysis

We investigated the role of antibodies against the mature portion of glycoprotein G (mgG-2) of herpes simplex virus 2 (HSV-2) in protective immunity after vaccination. Mice were immunized intramuscularly with mgG-2 and oligodeoxynucleotides containing two CpG motifs plus alum as adjuvant. All C57BL/...

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Bibliographic Details
Main Authors: Staffan Görander, Maria Ekblad, Tomas Bergström, Jan-Åke Liljeqvist
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Viruses
Subjects:
glycoprotein G
herpes simplex virus 2
vaccination
antibodies
Online Access:http://www.mdpi.com/1999-4915/6/11/4358

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