Nebulized levofloxacin for chronic Burkholderia cenocepacia pulmonary infection in cystic fibrosis: A case report
We present a patient with cystic fibrosis who used nebulized levofloxacin off-label to suppress chronic Burkholderia cenocepacia pulmonary infection. The patient was initially using tobramycin inhalation powder (TIP) off-label continuously for suppression of chronic B. cenocepacia; this was changed...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007122001940 |
| _version_ | 1811207460334075904 |
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| author | Renée VE. Dagenais Bradley S. Quon Alessandro N. Franciosi |
| author_facet | Renée VE. Dagenais Bradley S. Quon Alessandro N. Franciosi |
| author_sort | Renée VE. Dagenais |
| collection | DOAJ |
| description | We present a patient with cystic fibrosis who used nebulized levofloxacin off-label to suppress chronic Burkholderia cenocepacia pulmonary infection. The patient was initially using tobramycin inhalation powder (TIP) off-label continuously for suppression of chronic B. cenocepacia; this was changed to alternating months of nebulized levofloxacin and TIP. Following initiation of nebulized levofloxacin, the patient had significant improvement in respiratory symptom burden and lung function (as measured by forced expiratory volume in 1 second [FEV1]), and a decrease in the frequency of pulmonary exacerbations. Further research is necessary to determine whether the benefits observed with nebulized levofloxacin in our patient translate to a larger population of patients with chronic Burkholderia spp. pulmonary infection. |
| first_indexed | 2024-04-12T04:03:38Z |
| format | Article |
| id | doaj.art-0ebd9a6645f5492e89a683e71f79d559 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-04-12T04:03:38Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-0ebd9a6645f5492e89a683e71f79d5592022-12-22T03:48:39ZengElsevierRespiratory Medicine Case Reports2213-00712022-01-0140101772Nebulized levofloxacin for chronic Burkholderia cenocepacia pulmonary infection in cystic fibrosis: A case reportRenée VE. Dagenais0Bradley S. Quon1Alessandro N. Franciosi2Adult Cystic Fibrosis Program, St. Paul's Hospital, Vancouver, BC, V6Z 1Y6, Canada; Department of Pharmacy, St. Paul's Hospital, Vancouver, BC, V6Z 1Y6, Canada; Corresponding author. Adult Cystic Fibrosis Program St. Paul's Hospital, 1081 Burrard St. Vancouver, BC, V6Z 1Y6, Canada.Adult Cystic Fibrosis Program, St. Paul's Hospital, Vancouver, BC, V6Z 1Y6, Canada; Centre for Heart Lung Innovation, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, V6Z 1Y6, CanadaAdult Cystic Fibrosis Program, St. Paul's Hospital, Vancouver, BC, V6Z 1Y6, Canada; Centre for Heart Lung Innovation, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, V6Z 1Y6, CanadaWe present a patient with cystic fibrosis who used nebulized levofloxacin off-label to suppress chronic Burkholderia cenocepacia pulmonary infection. The patient was initially using tobramycin inhalation powder (TIP) off-label continuously for suppression of chronic B. cenocepacia; this was changed to alternating months of nebulized levofloxacin and TIP. Following initiation of nebulized levofloxacin, the patient had significant improvement in respiratory symptom burden and lung function (as measured by forced expiratory volume in 1 second [FEV1]), and a decrease in the frequency of pulmonary exacerbations. Further research is necessary to determine whether the benefits observed with nebulized levofloxacin in our patient translate to a larger population of patients with chronic Burkholderia spp. pulmonary infection.http://www.sciencedirect.com/science/article/pii/S2213007122001940NebulizedLevofloxacinBurkholderia cepacia complexCystic fibrosisInhaled antibiotics |
| spellingShingle | Renée VE. Dagenais Bradley S. Quon Alessandro N. Franciosi Nebulized levofloxacin for chronic Burkholderia cenocepacia pulmonary infection in cystic fibrosis: A case report Respiratory Medicine Case Reports Nebulized Levofloxacin Burkholderia cepacia complex Cystic fibrosis Inhaled antibiotics |
| title | Nebulized levofloxacin for chronic Burkholderia cenocepacia pulmonary infection in cystic fibrosis: A case report |
| title_full | Nebulized levofloxacin for chronic Burkholderia cenocepacia pulmonary infection in cystic fibrosis: A case report |
| title_fullStr | Nebulized levofloxacin for chronic Burkholderia cenocepacia pulmonary infection in cystic fibrosis: A case report |
| title_full_unstemmed | Nebulized levofloxacin for chronic Burkholderia cenocepacia pulmonary infection in cystic fibrosis: A case report |
| title_short | Nebulized levofloxacin for chronic Burkholderia cenocepacia pulmonary infection in cystic fibrosis: A case report |
| title_sort | nebulized levofloxacin for chronic burkholderia cenocepacia pulmonary infection in cystic fibrosis a case report |
| topic | Nebulized Levofloxacin Burkholderia cepacia complex Cystic fibrosis Inhaled antibiotics |
| url | http://www.sciencedirect.com/science/article/pii/S2213007122001940 |
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