Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic Cholecystectomy
Introduction: One of the most important problems that the patient faces after laparoscopic surgery is pain that is felt in the shoulders, back and abdomen. This study was designed to evaluate the effects of the combination of bupivacaine and ketamine and its intraperitoneal injection on reducing sho...
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| Format: | Article |
| Language: | fas |
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Shahid Sadoughi University of Medical Sciences
2023-02-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| Subjects: | |
| Online Access: | http://jssu.ssu.ac.ir/article-1-5462-en.html |
| _version_ | 1811164902689079296 |
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| author | Parvin Ziaei Saeed Kargar Mohammad Hossein Dehghan Farzan Madadizadeh Hamid Reza Jamshidi |
| author_facet | Parvin Ziaei Saeed Kargar Mohammad Hossein Dehghan Farzan Madadizadeh Hamid Reza Jamshidi |
| author_sort | Parvin Ziaei |
| collection | DOAJ |
| description | Introduction: One of the most important problems that the patient faces after laparoscopic surgery is pain that is felt in the shoulders, back and abdomen. This study was designed to evaluate the effects of the combination of bupivacaine and ketamine and its intraperitoneal injection on reducing shoulder pain after laparoscopic cholecystectomy.
Methods: This was a double-blind randomized study that included 90 patients undergoing elective surgery for laparoscopic cholecystectomy in the age group of 18-65 years and of both sexes. After removal of the gallbladder, 20 cc of solution was injected intraperitoneally at the surgical site. Patients were randomly assigned to three groups receiving 10 cc 0.5% bupivacaine + 0.5cc ketamine, the second group received 10 cc of %0.5 bupivacaine and 10 cc normal saline, the third group (control) received 20 cc of normal saline intraperitoneally. The findings were analyzed using SPSS version 16 software and repeated measurement analysis of variance and Bonferroni's pairwise comparison test.
Results: Analysis of variance showed that the mean pain scores were significantly different over time in each group (P<0.001). (P<0.001). Bonferroni paired comparison test showed that the lowest amount of pain was in the first group (p<0.05).
Conclusion: According to the results of the present study, intraperitoneal injection of ketamine combined with bupivacaine significantly (p<0.001) reduces pain up to 8 hours after laparoscopic cholecystectomy. |
| first_indexed | 2024-04-10T15:28:44Z |
| format | Article |
| id | doaj.art-0ebe1651982243148a71b3b0497672f0 |
| institution | Directory Open Access Journal |
| issn | 2228-5741 2228-5733 |
| language | fas |
| last_indexed | 2024-04-10T15:28:44Z |
| publishDate | 2023-02-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj.art-0ebe1651982243148a71b3b0497672f02023-02-14T06:12:56ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332023-02-01301161076117Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic CholecystectomyParvin Ziaei0Saeed Kargar1Mohammad Hossein Dehghan2Farzan Madadizadeh3Hamid Reza Jamshidi4 Department of Anesthesia, Faculty of Paramedicine, Shahid Sadougi University of Medical Sciences, Yazd, Iran. Department of Surgery, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Anesthesia, Faculty of Paramedicine, Shahid Sadougi University of Medical Sciences, Yazd, Iran. Department of Statistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadougi University of Medical Sciences, Yazd, Iran Introduction: One of the most important problems that the patient faces after laparoscopic surgery is pain that is felt in the shoulders, back and abdomen. This study was designed to evaluate the effects of the combination of bupivacaine and ketamine and its intraperitoneal injection on reducing shoulder pain after laparoscopic cholecystectomy. Methods: This was a double-blind randomized study that included 90 patients undergoing elective surgery for laparoscopic cholecystectomy in the age group of 18-65 years and of both sexes. After removal of the gallbladder, 20 cc of solution was injected intraperitoneally at the surgical site. Patients were randomly assigned to three groups receiving 10 cc 0.5% bupivacaine + 0.5cc ketamine, the second group received 10 cc of %0.5 bupivacaine and 10 cc normal saline, the third group (control) received 20 cc of normal saline intraperitoneally. The findings were analyzed using SPSS version 16 software and repeated measurement analysis of variance and Bonferroni's pairwise comparison test. Results: Analysis of variance showed that the mean pain scores were significantly different over time in each group (P<0.001). (P<0.001). Bonferroni paired comparison test showed that the lowest amount of pain was in the first group (p<0.05). Conclusion: According to the results of the present study, intraperitoneal injection of ketamine combined with bupivacaine significantly (p<0.001) reduces pain up to 8 hours after laparoscopic cholecystectomy.http://jssu.ssu.ac.ir/article-1-5462-en.htmllaparoscopic cholecystectomyshoulder painintraperitonealketaminebupivacaine. |
| spellingShingle | Parvin Ziaei Saeed Kargar Mohammad Hossein Dehghan Farzan Madadizadeh Hamid Reza Jamshidi Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic Cholecystectomy Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd laparoscopic cholecystectomy shoulder pain intraperitoneal ketamine bupivacaine. |
| title | Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic Cholecystectomy |
| title_full | Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic Cholecystectomy |
| title_fullStr | Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic Cholecystectomy |
| title_full_unstemmed | Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic Cholecystectomy |
| title_short | Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic Cholecystectomy |
| title_sort | clinical trial of intraperitoneal administration of ketamine combined with bupivacaine on pain status after laparoscopic cholecystectomy |
| topic | laparoscopic cholecystectomy shoulder pain intraperitoneal ketamine bupivacaine. |
| url | http://jssu.ssu.ac.ir/article-1-5462-en.html |
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