How autophagy, a potential therapeutic target, regulates intestinal inflammation
Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation in the intestines, with the primary types including ulcerative colitis and Crohn’s disease. The link between autophagy, a catabolic mechanism in which cells clear protein aggregates and damaged organelles, and i...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1087677/full |
| _version_ | 1797840520368619520 |
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| author | Shuang-Lan Chen Chun-Meng Li Wei Li Qing-Song Liu Shuang-Yuan Hu Mao-Yuan Zhao Dong-Sen Hu Yan-Wei Hao Jin-Hao Zeng Jin-Hao Zeng Yi Zhang |
| author_facet | Shuang-Lan Chen Chun-Meng Li Wei Li Qing-Song Liu Shuang-Yuan Hu Mao-Yuan Zhao Dong-Sen Hu Yan-Wei Hao Jin-Hao Zeng Jin-Hao Zeng Yi Zhang |
| author_sort | Shuang-Lan Chen |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation in the intestines, with the primary types including ulcerative colitis and Crohn’s disease. The link between autophagy, a catabolic mechanism in which cells clear protein aggregates and damaged organelles, and intestinal health has been widely studied. Experimental animal studies and human clinical studies have revealed that autophagy is pivotal for intestinal homeostasis maintenance, gut ecology regulation and other aspects. However, few articles have summarized and discussed the pathways by which autophagy improves or exacerbates IBD. Here, we review how autophagy alleviates IBD through the specific genes (e.g., ATG16L1, IRGM, NOD2 and LRRK2), crosstalk of multiple phenotypes with autophagy (e.g., Interaction of autophagy with endoplasmic reticulum stress, intestinal antimicrobial defense and apoptosis) and autophagy-associated signaling pathways. Moreover, we briefly discuss the role of autophagy in colorectal cancer and current status of autophagy-based drug research for IBD. It should be emphasized that autophagy has cell-specific and environment-specific effects on the gut. One of the problems of IBD research is to understand how autophagy plays a role in intestinal tract under specific environmental factors. A better understanding of the mechanism of autophagy in the occurrence and progression of IBD will provide references for the development of therapeutic drugs and disease management for IBD in the future. |
| first_indexed | 2024-04-09T16:16:41Z |
| format | Article |
| id | doaj.art-0ebf1d595a654be2a5a4ce5130e5b69b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T16:16:41Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0ebf1d595a654be2a5a4ce5130e5b69b2023-04-24T04:24:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.10876771087677How autophagy, a potential therapeutic target, regulates intestinal inflammationShuang-Lan Chen0Chun-Meng Li1Wei Li2Qing-Song Liu3Shuang-Yuan Hu4Mao-Yuan Zhao5Dong-Sen Hu6Yan-Wei Hao7Jin-Hao Zeng8Jin-Hao Zeng9Yi Zhang10Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Reproductive Medicine, Chengdu Xinan Women’s Hospital, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaInflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation in the intestines, with the primary types including ulcerative colitis and Crohn’s disease. The link between autophagy, a catabolic mechanism in which cells clear protein aggregates and damaged organelles, and intestinal health has been widely studied. Experimental animal studies and human clinical studies have revealed that autophagy is pivotal for intestinal homeostasis maintenance, gut ecology regulation and other aspects. However, few articles have summarized and discussed the pathways by which autophagy improves or exacerbates IBD. Here, we review how autophagy alleviates IBD through the specific genes (e.g., ATG16L1, IRGM, NOD2 and LRRK2), crosstalk of multiple phenotypes with autophagy (e.g., Interaction of autophagy with endoplasmic reticulum stress, intestinal antimicrobial defense and apoptosis) and autophagy-associated signaling pathways. Moreover, we briefly discuss the role of autophagy in colorectal cancer and current status of autophagy-based drug research for IBD. It should be emphasized that autophagy has cell-specific and environment-specific effects on the gut. One of the problems of IBD research is to understand how autophagy plays a role in intestinal tract under specific environmental factors. A better understanding of the mechanism of autophagy in the occurrence and progression of IBD will provide references for the development of therapeutic drugs and disease management for IBD in the future.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1087677/fullsignaling pathwayinflammatory bowel diseaseautophagyautophagy-associated geneendoplasmic reticulum stressintestinal microflora |
| spellingShingle | Shuang-Lan Chen Chun-Meng Li Wei Li Qing-Song Liu Shuang-Yuan Hu Mao-Yuan Zhao Dong-Sen Hu Yan-Wei Hao Jin-Hao Zeng Jin-Hao Zeng Yi Zhang How autophagy, a potential therapeutic target, regulates intestinal inflammation Frontiers in Immunology signaling pathway inflammatory bowel disease autophagy autophagy-associated gene endoplasmic reticulum stress intestinal microflora |
| title | How autophagy, a potential therapeutic target, regulates intestinal inflammation |
| title_full | How autophagy, a potential therapeutic target, regulates intestinal inflammation |
| title_fullStr | How autophagy, a potential therapeutic target, regulates intestinal inflammation |
| title_full_unstemmed | How autophagy, a potential therapeutic target, regulates intestinal inflammation |
| title_short | How autophagy, a potential therapeutic target, regulates intestinal inflammation |
| title_sort | how autophagy a potential therapeutic target regulates intestinal inflammation |
| topic | signaling pathway inflammatory bowel disease autophagy autophagy-associated gene endoplasmic reticulum stress intestinal microflora |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1087677/full |
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