Medication-related osteonecrosis of the jaw: Prosthodontic considerations
Medication-related osteonecrosis of the jaw (MRONJ) can be triggered by several antiresorptive and antiangiogenic medications, including bisphosphonates (BRONJ), denosumab (DRONJ), and other agents used to treat osteoporosis and metastatic bone cancer. Prosthodontists and surgeons continue to face n...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761621000430 |
| _version_ | 1797977722001031168 |
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| author | Islam E. Ali Yuka Sumita |
| author_facet | Islam E. Ali Yuka Sumita |
| author_sort | Islam E. Ali |
| collection | DOAJ |
| description | Medication-related osteonecrosis of the jaw (MRONJ) can be triggered by several antiresorptive and antiangiogenic medications, including bisphosphonates (BRONJ), denosumab (DRONJ), and other agents used to treat osteoporosis and metastatic bone cancer. Prosthodontists and surgeons continue to face new challenges because of this condition. Despite the current evidence showing that extensive surgical intervention and laser surgery have the highest healing rates, surgical reconstruction is not always possible for large jaw defects requiring prosthetic reconstruction. Moreover, surgical treatment may not be an option in some patients because of other medical conditions. In these patients, MRONJ may develop into a chronic disease with limited resolution and they may seek prosthetic rehabilitation for aesthetic and functional reasons. Therefore, prosthetic intervention may be necessary for some patients with MRONJ even in the absence of a surgical defect. Denture trauma has been reported to be a risk factor for MRONJ, and few reports have discussed the prosthodontic considerations needed for patients with this condition. The aim of this review is to highlight the prosthodontic considerations that would decrease the risk of triggering MRONJ in susceptible patients. |
| first_indexed | 2024-04-11T05:11:31Z |
| format | Article |
| id | doaj.art-0ec009828d4f419e8dbd5d69679b3f94 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-04-11T05:11:31Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-0ec009828d4f419e8dbd5d69679b3f942022-12-25T04:17:14ZengElsevierJapanese Dental Science Review1882-76162022-11-0158912Medication-related osteonecrosis of the jaw: Prosthodontic considerationsIslam E. Ali0Yuka Sumita1Department of Maxillofacial Prosthetics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Department of Prosthodontics, Faculty of Dentistry, Mansoura University, Mansoura, EgyptDepartment of Maxillofacial Prosthetics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Corresponding author at: Department of Maxillofacial Prosthetics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8549, Japan.Medication-related osteonecrosis of the jaw (MRONJ) can be triggered by several antiresorptive and antiangiogenic medications, including bisphosphonates (BRONJ), denosumab (DRONJ), and other agents used to treat osteoporosis and metastatic bone cancer. Prosthodontists and surgeons continue to face new challenges because of this condition. Despite the current evidence showing that extensive surgical intervention and laser surgery have the highest healing rates, surgical reconstruction is not always possible for large jaw defects requiring prosthetic reconstruction. Moreover, surgical treatment may not be an option in some patients because of other medical conditions. In these patients, MRONJ may develop into a chronic disease with limited resolution and they may seek prosthetic rehabilitation for aesthetic and functional reasons. Therefore, prosthetic intervention may be necessary for some patients with MRONJ even in the absence of a surgical defect. Denture trauma has been reported to be a risk factor for MRONJ, and few reports have discussed the prosthodontic considerations needed for patients with this condition. The aim of this review is to highlight the prosthodontic considerations that would decrease the risk of triggering MRONJ in susceptible patients.http://www.sciencedirect.com/science/article/pii/S1882761621000430BisphosphonatesDenosumabAntiresorptive agentsMedication-related osteonecrosis of the jawProsthodontic considerations |
| spellingShingle | Islam E. Ali Yuka Sumita Medication-related osteonecrosis of the jaw: Prosthodontic considerations Japanese Dental Science Review Bisphosphonates Denosumab Antiresorptive agents Medication-related osteonecrosis of the jaw Prosthodontic considerations |
| title | Medication-related osteonecrosis of the jaw: Prosthodontic considerations |
| title_full | Medication-related osteonecrosis of the jaw: Prosthodontic considerations |
| title_fullStr | Medication-related osteonecrosis of the jaw: Prosthodontic considerations |
| title_full_unstemmed | Medication-related osteonecrosis of the jaw: Prosthodontic considerations |
| title_short | Medication-related osteonecrosis of the jaw: Prosthodontic considerations |
| title_sort | medication related osteonecrosis of the jaw prosthodontic considerations |
| topic | Bisphosphonates Denosumab Antiresorptive agents Medication-related osteonecrosis of the jaw Prosthodontic considerations |
| url | http://www.sciencedirect.com/science/article/pii/S1882761621000430 |
| work_keys_str_mv | AT islameali medicationrelatedosteonecrosisofthejawprosthodonticconsiderations AT yukasumita medicationrelatedosteonecrosisofthejawprosthodonticconsiderations |