Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms
The actions of fibroblast growth factors (FGFs), particularly the basic form (bFGF), have been described in a large number of cells and include mitogenicity, angiogenicity and wound repair. The present review discusses the presence of the bFGF protein and messenger RNA as well as the presence of the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
1998-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200007 |
| _version_ | 1818266876509159424 |
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| author | Chadi G. Fuxe K. |
| author_facet | Chadi G. Fuxe K. |
| author_sort | Chadi G. |
| collection | DOAJ |
| description | The actions of fibroblast growth factors (FGFs), particularly the basic form (bFGF), have been described in a large number of cells and include mitogenicity, angiogenicity and wound repair. The present review discusses the presence of the bFGF protein and messenger RNA as well as the presence of the FGF receptor messenger RNA in the rodent brain by means of semiquantitative radioactive in situ hybridization in combination with immunohistochemistry. Chemical and mechanical injuries to the brain trigger a reduction in neurotransmitter synthesis and neuronal death which are accompanied by astroglial reaction. The altered synthesis of bFGF following brain lesions or stimulation was analyzed. Lesions of the central nervous system trigger bFGF gene expression by neurons and/or activated astrocytes, depending on the type of lesion and time post-manipulation. The changes in bFGF messenger RNA are frequently accompanied by a subsequent increase of bFGF immunoreactivity in astrocytes in the lesioned pathway. The reactive astrocytes and injured neurons synthesize increased amount of bFGF, which may act as a paracrine/autocrine factor, protecting neurons from death and also stimulating neuronal plasticity and tissue repair |
| first_indexed | 2024-12-12T20:13:40Z |
| format | Article |
| id | doaj.art-0ec22950ee334492a353723bbc68f32e |
| institution | Directory Open Access Journal |
| issn | 0100-879X 0034-7310 |
| language | English |
| last_indexed | 2024-12-12T20:13:40Z |
| publishDate | 1998-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-0ec22950ee334492a353723bbc68f32e2022-12-22T00:13:26ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73101998-01-01312231241Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanismsChadi G.Fuxe K.The actions of fibroblast growth factors (FGFs), particularly the basic form (bFGF), have been described in a large number of cells and include mitogenicity, angiogenicity and wound repair. The present review discusses the presence of the bFGF protein and messenger RNA as well as the presence of the FGF receptor messenger RNA in the rodent brain by means of semiquantitative radioactive in situ hybridization in combination with immunohistochemistry. Chemical and mechanical injuries to the brain trigger a reduction in neurotransmitter synthesis and neuronal death which are accompanied by astroglial reaction. The altered synthesis of bFGF following brain lesions or stimulation was analyzed. Lesions of the central nervous system trigger bFGF gene expression by neurons and/or activated astrocytes, depending on the type of lesion and time post-manipulation. The changes in bFGF messenger RNA are frequently accompanied by a subsequent increase of bFGF immunoreactivity in astrocytes in the lesioned pathway. The reactive astrocytes and injured neurons synthesize increased amount of bFGF, which may act as a paracrine/autocrine factor, protecting neurons from death and also stimulating neuronal plasticity and tissue repairhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200007radioautographyin situ hybridizationbasic fibroblast growth factorFGF receptorastrocyteimage analysiscentral nervous systembrain lesion |
| spellingShingle | Chadi G. Fuxe K. Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms Brazilian Journal of Medical and Biological Research radioautography in situ hybridization basic fibroblast growth factor FGF receptor astrocyte image analysis central nervous system brain lesion |
| title | Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms |
| title_full | Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms |
| title_fullStr | Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms |
| title_full_unstemmed | Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms |
| title_short | Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms |
| title_sort | analysis of trophic responses in lesioned brain focus on basic fibroblast growth factor mechanisms |
| topic | radioautography in situ hybridization basic fibroblast growth factor FGF receptor astrocyte image analysis central nervous system brain lesion |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200007 |
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