Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional survey
IntroductionAlongside the improved survival of nasopharyngeal cancer (NPC), late radiation toxicities are alarmingly hampering survivors’ quality of life. A patient-reported symptom burden survey is lacking to address the unmet need for symptom management among local NPC survivors.MethodsA single-ce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1378973/full |
| _version_ | 1827278704726769664 |
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| author | Victor C. W. Tam Victor C. W. Tam Jerry C. F. Ching Sindy S. T. Yip Virginia H. Y. Kwong Catherine P. L. Chan Kenneth C. W. Wong Shara W. Y. Lee |
| author_facet | Victor C. W. Tam Victor C. W. Tam Jerry C. F. Ching Sindy S. T. Yip Virginia H. Y. Kwong Catherine P. L. Chan Kenneth C. W. Wong Shara W. Y. Lee |
| author_sort | Victor C. W. Tam |
| collection | DOAJ |
| description | IntroductionAlongside the improved survival of nasopharyngeal cancer (NPC), late radiation toxicities are alarmingly hampering survivors’ quality of life. A patient-reported symptom burden survey is lacking to address the unmet need for symptom management among local NPC survivors.MethodsA single-center cross-sectional survey was conducted on 211 NPC survivors who had completed radiation therapy for three to 120 months. We employed the Chinese version M. D. Anderson Symptom Inventory - Head & Neck Module (MDASI-HN-C), Functional Assessment of Cancer Therapy - Head & Neck (FACT-HN-C), and a question extracted from the Cancer Survivors’ Unmet Needs Measure (CaSUN).ResultsTwo hundred valid responses were collected. Participants suffered from at least four moderate to severe symptoms (mean = 4.84, SD = 4.99). The top five severe symptoms were dry mouth, mucus problems, difficulty swallowing or chewing, teeth or gum problems, and memory problems. MDASI-HN-C subscales were negatively correlated with the physical, emotional, functional, and HN-specific domains of the FACT-HN-C. The unmet need for symptom management was positively associated with symptom burden, either general symptoms (Adjusted odds ratio [ORadj] = 1.566, 95% CI = 1.282 – 1.914, p < 0.001) or top-5 symptoms (ORadj = 1.379, 95% CI = 1.185 – 1.604, p < 0.001), while negatively associated with post-RT time (ORadj = 0.981, 95% CI [0.972, 0.991], p < 0.001).ConclusionVirtually all NPC survivors suffer from late toxicities, which interplay with survivors’ perceptions intricately to affect their unmet needs for symptom management. Personalized supportive care strategies with regular assessments and stratifications are warranted. |
| first_indexed | 2024-04-24T08:05:44Z |
| format | Article |
| id | doaj.art-0ec2d986e2e04724a1ed1ce6c7815627 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T08:05:44Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0ec2d986e2e04724a1ed1ce6c78156272024-04-17T10:16:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.13789731378973Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional surveyVictor C. W. Tam0Victor C. W. Tam1Jerry C. F. Ching2Sindy S. T. Yip3Virginia H. Y. Kwong4Catherine P. L. Chan5Kenneth C. W. Wong6Shara W. Y. Lee7Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, ChinaDepartment of Clinical Oncology, Prince of Wales Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, ChinaDepartment of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, ChinaDepartment of Clinical Oncology, Prince of Wales Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Clinical Oncology, Prince of Wales Hospital, Hong Kong, Hong Kong SAR, ChinaDepartment of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, ChinaIntroductionAlongside the improved survival of nasopharyngeal cancer (NPC), late radiation toxicities are alarmingly hampering survivors’ quality of life. A patient-reported symptom burden survey is lacking to address the unmet need for symptom management among local NPC survivors.MethodsA single-center cross-sectional survey was conducted on 211 NPC survivors who had completed radiation therapy for three to 120 months. We employed the Chinese version M. D. Anderson Symptom Inventory - Head & Neck Module (MDASI-HN-C), Functional Assessment of Cancer Therapy - Head & Neck (FACT-HN-C), and a question extracted from the Cancer Survivors’ Unmet Needs Measure (CaSUN).ResultsTwo hundred valid responses were collected. Participants suffered from at least four moderate to severe symptoms (mean = 4.84, SD = 4.99). The top five severe symptoms were dry mouth, mucus problems, difficulty swallowing or chewing, teeth or gum problems, and memory problems. MDASI-HN-C subscales were negatively correlated with the physical, emotional, functional, and HN-specific domains of the FACT-HN-C. The unmet need for symptom management was positively associated with symptom burden, either general symptoms (Adjusted odds ratio [ORadj] = 1.566, 95% CI = 1.282 – 1.914, p < 0.001) or top-5 symptoms (ORadj = 1.379, 95% CI = 1.185 – 1.604, p < 0.001), while negatively associated with post-RT time (ORadj = 0.981, 95% CI [0.972, 0.991], p < 0.001).ConclusionVirtually all NPC survivors suffer from late toxicities, which interplay with survivors’ perceptions intricately to affect their unmet needs for symptom management. Personalized supportive care strategies with regular assessments and stratifications are warranted.https://www.frontiersin.org/articles/10.3389/fonc.2024.1378973/fullnasopharyngeal cancersurvivorshipradiation therapylate toxicitiessymptom burdenunmet need |
| spellingShingle | Victor C. W. Tam Victor C. W. Tam Jerry C. F. Ching Sindy S. T. Yip Virginia H. Y. Kwong Catherine P. L. Chan Kenneth C. W. Wong Shara W. Y. Lee Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional survey Frontiers in Oncology nasopharyngeal cancer survivorship radiation therapy late toxicities symptom burden unmet need |
| title | Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional survey |
| title_full | Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional survey |
| title_fullStr | Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional survey |
| title_full_unstemmed | Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional survey |
| title_short | Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional survey |
| title_sort | examining patient reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors a cross sectional survey |
| topic | nasopharyngeal cancer survivorship radiation therapy late toxicities symptom burden unmet need |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1378973/full |
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