Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota
Proton pump inhibitors (PPIs) are the most used acid-inhibitory drugs, with a wide range of applications in the treatment of various digestive diseases. However, recently, there has been a growing number of digestive complications linked to PPIs, and several studies have indicated that the intestina...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1217306/full |
| _version_ | 1797778287794061312 |
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| author | Liang Tian Chongfei Huang Wenkang Fu Long Gao Ningning Mi Mingzhen Bai Haidong Ma Chao Zhang Yawen Lu Jinyu Zhao Xianzhuo Zhang Ningzu Jiang Yanyan Lin Ping Yue Jinqiu Yuan Wenbo Meng Wenbo Meng |
| author_facet | Liang Tian Chongfei Huang Wenkang Fu Long Gao Ningning Mi Mingzhen Bai Haidong Ma Chao Zhang Yawen Lu Jinyu Zhao Xianzhuo Zhang Ningzu Jiang Yanyan Lin Ping Yue Jinqiu Yuan Wenbo Meng Wenbo Meng |
| author_sort | Liang Tian |
| collection | DOAJ |
| description | Proton pump inhibitors (PPIs) are the most used acid-inhibitory drugs, with a wide range of applications in the treatment of various digestive diseases. However, recently, there has been a growing number of digestive complications linked to PPIs, and several studies have indicated that the intestinal flora play an important role in these complications. Therefore, developing a greater understanding of the role of the gut microbiota in PPI-related digestive diseases is essential. Here, we summarize the current research on the correlation between PPI-related digestive disorders and intestinal flora and establish the altered strains and possible pathogenic mechanisms of the different diseases. We aimed to provide a theoretical basis and reference for the future treatment and prevention of PPI-related digestive complications based on the regulation of the intestinal microbiota. |
| first_indexed | 2024-03-12T23:16:04Z |
| format | Article |
| id | doaj.art-0ec3c140d7084ec6b92040662dd467de |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T23:16:04Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0ec3c140d7084ec6b92040662dd467de2023-07-17T06:45:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-07-011410.3389/fphar.2023.12173061217306Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiotaLiang Tian0Chongfei Huang1Wenkang Fu2Long Gao3Ningning Mi4Mingzhen Bai5Haidong Ma6Chao Zhang7Yawen Lu8Jinyu Zhao9Xianzhuo Zhang10Ningzu Jiang11Yanyan Lin12Ping Yue13Jinqiu Yuan14Wenbo Meng15Wenbo Meng16The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaClinical Research Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, ChinaProton pump inhibitors (PPIs) are the most used acid-inhibitory drugs, with a wide range of applications in the treatment of various digestive diseases. However, recently, there has been a growing number of digestive complications linked to PPIs, and several studies have indicated that the intestinal flora play an important role in these complications. Therefore, developing a greater understanding of the role of the gut microbiota in PPI-related digestive diseases is essential. Here, we summarize the current research on the correlation between PPI-related digestive disorders and intestinal flora and establish the altered strains and possible pathogenic mechanisms of the different diseases. We aimed to provide a theoretical basis and reference for the future treatment and prevention of PPI-related digestive complications based on the regulation of the intestinal microbiota.https://www.frontiersin.org/articles/10.3389/fphar.2023.1217306/fullproton pump inhibitorsdigestive diseasesmicrobiotaintestinal floraClostridium difficileinflammatory bowel disease |
| spellingShingle | Liang Tian Chongfei Huang Wenkang Fu Long Gao Ningning Mi Mingzhen Bai Haidong Ma Chao Zhang Yawen Lu Jinyu Zhao Xianzhuo Zhang Ningzu Jiang Yanyan Lin Ping Yue Jinqiu Yuan Wenbo Meng Wenbo Meng Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota Frontiers in Pharmacology proton pump inhibitors digestive diseases microbiota intestinal flora Clostridium difficile inflammatory bowel disease |
| title | Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota |
| title_full | Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota |
| title_fullStr | Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota |
| title_full_unstemmed | Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota |
| title_short | Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota |
| title_sort | proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota |
| topic | proton pump inhibitors digestive diseases microbiota intestinal flora Clostridium difficile inflammatory bowel disease |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1217306/full |
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