Role of protein Post-translational modifications in enterovirus infection
Enteroviruses (EVs) are the main cause of a number of neurological diseases. Growing evidence has revealed that successful infection with enteroviruses is highly dependent on the host machinery, therefore, host proteins play a pivotal role in viral infections. Both host and viral proteins can underg...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1341599/full |
| _version_ | 1827308553026666496 |
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| author | Xiaohui Zhao Yibo Hu Jun Zhao Yan Liu Xueman Ma Hongru Chen Yonghua Xing |
| author_facet | Xiaohui Zhao Yibo Hu Jun Zhao Yan Liu Xueman Ma Hongru Chen Yonghua Xing |
| author_sort | Xiaohui Zhao |
| collection | DOAJ |
| description | Enteroviruses (EVs) are the main cause of a number of neurological diseases. Growing evidence has revealed that successful infection with enteroviruses is highly dependent on the host machinery, therefore, host proteins play a pivotal role in viral infections. Both host and viral proteins can undergo post-translational modification (PTM) which can regulate protein activity, stability, solubility and interactions with other proteins; thereby influencing various biological processes, including cell metabolism, metabolic, signaling pathways, cell death, and cancer development. During viral infection, both host and viral proteins regulate the viral life cycle through various PTMs and different mechanisms, including the regulation of host cell entry, viral protein synthesis, genome replication, and the antiviral immune response. Therefore, protein PTMs play important roles in EV infections. Here, we review the role of various host- and virus-associated PTMs during enterovirus infection. |
| first_indexed | 2024-04-24T19:10:15Z |
| format | Article |
| id | doaj.art-0ec64e4f454d4698a67d6ca3c9f9f22b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T19:10:15Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0ec64e4f454d4698a67d6ca3c9f9f22b2024-03-26T10:22:29ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-02-011510.3389/fmicb.2024.13415991341599Role of protein Post-translational modifications in enterovirus infectionXiaohui Zhao0Yibo Hu1Jun Zhao2Yan Liu3Xueman Ma4Hongru Chen5Yonghua Xing6Department of Pathogen Biology, School of Medicine, Qinghai University, Qinghai, ChinaDepartment of Orthopaedic Trauma, The Affiliated Hospital of Qinghai University, Qinghai, ChinaDepartment of Pathogen Biology, School of Medicine, Qinghai University, Qinghai, ChinaDepartment of Immunology, School of Medicine, Qinghai, ChinaDepartment of Traditional Chinese Medicine, School of Medicine, Qinghai University, Qinghai, ChinaDepartment of Public Health, School of Medicine, Qinghai University, Qinghai, ChinaDepartment of Genetics, School of Medicine, Qinghai University, Qinghai, ChinaEnteroviruses (EVs) are the main cause of a number of neurological diseases. Growing evidence has revealed that successful infection with enteroviruses is highly dependent on the host machinery, therefore, host proteins play a pivotal role in viral infections. Both host and viral proteins can undergo post-translational modification (PTM) which can regulate protein activity, stability, solubility and interactions with other proteins; thereby influencing various biological processes, including cell metabolism, metabolic, signaling pathways, cell death, and cancer development. During viral infection, both host and viral proteins regulate the viral life cycle through various PTMs and different mechanisms, including the regulation of host cell entry, viral protein synthesis, genome replication, and the antiviral immune response. Therefore, protein PTMs play important roles in EV infections. Here, we review the role of various host- and virus-associated PTMs during enterovirus infection.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1341599/fullenterovirus infectionpost-translation modificationhost factorspathogenesisenterovirus life cycle |
| spellingShingle | Xiaohui Zhao Yibo Hu Jun Zhao Yan Liu Xueman Ma Hongru Chen Yonghua Xing Role of protein Post-translational modifications in enterovirus infection Frontiers in Microbiology enterovirus infection post-translation modification host factors pathogenesis enterovirus life cycle |
| title | Role of protein Post-translational modifications in enterovirus infection |
| title_full | Role of protein Post-translational modifications in enterovirus infection |
| title_fullStr | Role of protein Post-translational modifications in enterovirus infection |
| title_full_unstemmed | Role of protein Post-translational modifications in enterovirus infection |
| title_short | Role of protein Post-translational modifications in enterovirus infection |
| title_sort | role of protein post translational modifications in enterovirus infection |
| topic | enterovirus infection post-translation modification host factors pathogenesis enterovirus life cycle |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1341599/full |
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