Effective Synthesis of Deuterated n-Octylamine and Its Analogues
In neutron scattering studies, deuterium-labelled compounds play a key role in controlling the contrast of organic samples and reducing the incoherent scattering background from the samples. As amine compounds play a vital role as functional molecules, we have developed a new synthesis method using...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | EPJ Web of Conferences |
| Online Access: | https://www.epj-conferences.org/articles/epjconf/pdf/2023/12/epjconf_ecns2023_01004.pdf |
| _version_ | 1797658484788953088 |
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| author | Akutsu-Suyama Kazuhiro Ueda Misaki Shibayama Mitsuhiro Ishii Kosuke Nishi Naoya |
| author_facet | Akutsu-Suyama Kazuhiro Ueda Misaki Shibayama Mitsuhiro Ishii Kosuke Nishi Naoya |
| author_sort | Akutsu-Suyama Kazuhiro |
| collection | DOAJ |
| description | In neutron scattering studies, deuterium-labelled compounds play a key role in controlling the contrast of organic samples and reducing the incoherent scattering background from the samples. As amine compounds play a vital role as functional molecules, we have developed a new synthesis method using an amide compound as a starting material to synthesize deuterated amines and their analogues. We determined the deuteration ratio of the obtained deuterated 1-octylamine by mass spectrometry, nuclear magnetic resonance (NMR), and neutron reflectometry techniques. As a result, the deuteration ratio was estimated to be ~60 %. The deuteration ratio of the synthesized 1-octylamine was not high because the method used did not deuterate its α-protons and NH2 group. However, this synthesis method is suitable for the large-scale synthesis of deuterated amine compounds for neutron research because it is easy to increase the synthetic scale. |
| first_indexed | 2024-03-11T18:00:43Z |
| format | Article |
| id | doaj.art-0ec7a1749cf04188be9b197a174bd129 |
| institution | Directory Open Access Journal |
| issn | 2100-014X |
| language | English |
| last_indexed | 2024-03-11T18:00:43Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | EPJ Web of Conferences |
| spelling | doaj.art-0ec7a1749cf04188be9b197a174bd1292023-10-17T08:54:29ZengEDP SciencesEPJ Web of Conferences2100-014X2023-01-012860100410.1051/epjconf/202328601004epjconf_ecns2023_01004Effective Synthesis of Deuterated n-Octylamine and Its AnaloguesAkutsu-Suyama Kazuhiro0Ueda Misaki1Shibayama Mitsuhiro2Ishii Kosuke3Nishi Naoya4Neutron Science and Technology Center, Comprehensive Research Organization for Science and SocietyNeutron Science and Technology Center, Comprehensive Research Organization for Science and SocietyNeutron Science and Technology Center, Comprehensive Research Organization for Science and SocietyDepartment of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto UniversityDepartment of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto UniversityIn neutron scattering studies, deuterium-labelled compounds play a key role in controlling the contrast of organic samples and reducing the incoherent scattering background from the samples. As amine compounds play a vital role as functional molecules, we have developed a new synthesis method using an amide compound as a starting material to synthesize deuterated amines and their analogues. We determined the deuteration ratio of the obtained deuterated 1-octylamine by mass spectrometry, nuclear magnetic resonance (NMR), and neutron reflectometry techniques. As a result, the deuteration ratio was estimated to be ~60 %. The deuteration ratio of the synthesized 1-octylamine was not high because the method used did not deuterate its α-protons and NH2 group. However, this synthesis method is suitable for the large-scale synthesis of deuterated amine compounds for neutron research because it is easy to increase the synthetic scale.https://www.epj-conferences.org/articles/epjconf/pdf/2023/12/epjconf_ecns2023_01004.pdf |
| spellingShingle | Akutsu-Suyama Kazuhiro Ueda Misaki Shibayama Mitsuhiro Ishii Kosuke Nishi Naoya Effective Synthesis of Deuterated n-Octylamine and Its Analogues EPJ Web of Conferences |
| title | Effective Synthesis of Deuterated n-Octylamine and Its Analogues |
| title_full | Effective Synthesis of Deuterated n-Octylamine and Its Analogues |
| title_fullStr | Effective Synthesis of Deuterated n-Octylamine and Its Analogues |
| title_full_unstemmed | Effective Synthesis of Deuterated n-Octylamine and Its Analogues |
| title_short | Effective Synthesis of Deuterated n-Octylamine and Its Analogues |
| title_sort | effective synthesis of deuterated n octylamine and its analogues |
| url | https://www.epj-conferences.org/articles/epjconf/pdf/2023/12/epjconf_ecns2023_01004.pdf |
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