Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations
Given the tubal origin of high-grade serous ovarian cancer (HGSC), we sought to investigate intrauterine lavage (IUL) as a novel method of biomarker detection. IUL and serum samples were collected from patients with HGSC or benign pathology. Although CA-125 and HE4 concentrations were significantly...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578924000092 |
| _version_ | 1827345979605516288 |
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| author | Tiffany Y. Sia Zvi Yaari Ron Feiner Evan Smith Arnaud Da Cruz Paula Pier Selenica Sital Doddi Dennis S. Chi Nadeem R. Abu-Rustum Douglas A. Levine Britta Weigelt Martin Fleisher Lakshmi V. Ramanathan Daniel A. Heller Kara Long Roche |
| author_facet | Tiffany Y. Sia Zvi Yaari Ron Feiner Evan Smith Arnaud Da Cruz Paula Pier Selenica Sital Doddi Dennis S. Chi Nadeem R. Abu-Rustum Douglas A. Levine Britta Weigelt Martin Fleisher Lakshmi V. Ramanathan Daniel A. Heller Kara Long Roche |
| author_sort | Tiffany Y. Sia |
| collection | DOAJ |
| description | Given the tubal origin of high-grade serous ovarian cancer (HGSC), we sought to investigate intrauterine lavage (IUL) as a novel method of biomarker detection. IUL and serum samples were collected from patients with HGSC or benign pathology. Although CA-125 and HE4 concentrations were significantly higher in IUL samples compared to serum, they were similar between IUL samples from patients with HGSC vs benign conditions. In contrast, CA-125 and HE4 serum concentrations differed between HGSC and benign pathology (P =.002 for both). IUL and tumor samples from patients with HGSC were subjected to targeted panel sequencing and droplet digital PCR (ddPCR). Tumor mutations were found in 75 % of matched IUL samples. Serum CA-125 and HE4 biomarker levels allowed for better differentiation of HGSC and benign pathology compared to IUL samples. We believe using IUL for early detection of HGSC requires optimization, and current strategies should focus on prevention until early detection strategies improve. |
| first_indexed | 2024-03-07T23:21:31Z |
| format | Article |
| id | doaj.art-0ec9b8149c314a47adc99948d4bc2357 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-03-07T23:21:31Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-0ec9b8149c314a47adc99948d4bc23572024-02-21T05:28:50ZengElsevierGynecologic Oncology Reports2352-57892024-02-0151101330Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulationsTiffany Y. Sia0Zvi Yaari1Ron Feiner2Evan Smith3Arnaud Da Cruz Paula4Pier Selenica5Sital Doddi6Dennis S. Chi7Nadeem R. Abu-Rustum8Douglas A. Levine9Britta Weigelt10Martin Fleisher11Lakshmi V. Ramanathan12Daniel A. Heller13Kara Long Roche14Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USASchool of Pharmacy, Department of Medicine, Hebrew University of Jerusalem, IsraelDepartment of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USAi3S Instituto de Investigação e Inovação em Saúde, Porto, Portugal; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of OB/GYN, Weill Cornell Medical College, New York, NY, USADepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of OB/GYN, Weill Cornell Medical College, New York, NY, USAMerck Research Laboratories, Rahway, NJ, USADepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USAMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, USADepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of OB/GYN, Weill Cornell Medical College, New York, NY, USA; Corresponding author at: Gynecologic Oncology Fellowship Program, Section of Ovarian Cancer Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Howard 13, New York, NY 10065, USA.Given the tubal origin of high-grade serous ovarian cancer (HGSC), we sought to investigate intrauterine lavage (IUL) as a novel method of biomarker detection. IUL and serum samples were collected from patients with HGSC or benign pathology. Although CA-125 and HE4 concentrations were significantly higher in IUL samples compared to serum, they were similar between IUL samples from patients with HGSC vs benign conditions. In contrast, CA-125 and HE4 serum concentrations differed between HGSC and benign pathology (P =.002 for both). IUL and tumor samples from patients with HGSC were subjected to targeted panel sequencing and droplet digital PCR (ddPCR). Tumor mutations were found in 75 % of matched IUL samples. Serum CA-125 and HE4 biomarker levels allowed for better differentiation of HGSC and benign pathology compared to IUL samples. We believe using IUL for early detection of HGSC requires optimization, and current strategies should focus on prevention until early detection strategies improve.http://www.sciencedirect.com/science/article/pii/S2352578924000092Ovarian cancerIntrauterine lavageEarly detection |
| spellingShingle | Tiffany Y. Sia Zvi Yaari Ron Feiner Evan Smith Arnaud Da Cruz Paula Pier Selenica Sital Doddi Dennis S. Chi Nadeem R. Abu-Rustum Douglas A. Levine Britta Weigelt Martin Fleisher Lakshmi V. Ramanathan Daniel A. Heller Kara Long Roche Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations Gynecologic Oncology Reports Ovarian cancer Intrauterine lavage Early detection |
| title | Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations |
| title_full | Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations |
| title_fullStr | Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations |
| title_full_unstemmed | Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations |
| title_short | Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations |
| title_sort | uterine washings as a novel method for early detection of ovarian cancer trials and tribulations |
| topic | Ovarian cancer Intrauterine lavage Early detection |
| url | http://www.sciencedirect.com/science/article/pii/S2352578924000092 |
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