The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus
Tembusu virus (TMUV) can induce severe egg drop syndrome in ducks, causing significant economic losses. In this study, the possible origin, genomic epidemiology, and transmission dynamics of TMUV were determined. The time to the most recent common ancestor of TMUV was found to be 1924, earlier than...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/14/6/1236 |
| _version_ | 1797481395721863168 |
|---|---|
| author | Yongqiu Cui Yang Pan Jinshuo Guo Dedong Wang Xinxin Tong Yongxia Wang Jingyi Li Jie Zhao Ying Ji Zhi Wu Penghui Zeng Jianwei Zhou Xufei Feng Lei Hou Jue Liu |
| author_facet | Yongqiu Cui Yang Pan Jinshuo Guo Dedong Wang Xinxin Tong Yongxia Wang Jingyi Li Jie Zhao Ying Ji Zhi Wu Penghui Zeng Jianwei Zhou Xufei Feng Lei Hou Jue Liu |
| author_sort | Yongqiu Cui |
| collection | DOAJ |
| description | Tembusu virus (TMUV) can induce severe egg drop syndrome in ducks, causing significant economic losses. In this study, the possible origin, genomic epidemiology, and transmission dynamics of TMUV were determined. The time to the most recent common ancestor of TMUV was found to be 1924, earlier than that previously reported. The effective population size of TMUV increased rapidly from 2010 to 2013 and was associated with the diversification of different TMUV clusters. TMUV was classified into three clusters (clusters 1, 2, and 3) based on the envelope (E) protein. Subcluster 2.2, within cluster 2, is the most prevalent, and the occurrence of these mutations is accompanied by changes in the virulence and infectivity of the virus. Two positive selections on codons located in the <i>NS3</i> and <i>NS5</i> genes (591 of NS3 and 883 of NS5) were identified, which might have caused changes in the ability of the virus to replicate. Based on phylogeographic analysis, Malaysia was the most likely country of origin for TMUV, while Shandong Province was the earliest province of origin in China. This study has important implications for understanding TMUV and provides suggestions for its prevention and control. |
| first_indexed | 2024-03-09T22:13:58Z |
| format | Article |
| id | doaj.art-0ecaf1d45e854cdba065586ad3e7c302 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T22:13:58Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-0ecaf1d45e854cdba065586ad3e7c3022023-11-23T19:25:59ZengMDPI AGViruses1999-49152022-06-01146123610.3390/v14061236The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu VirusYongqiu Cui0Yang Pan1Jinshuo Guo2Dedong Wang3Xinxin Tong4Yongxia Wang5Jingyi Li6Jie Zhao7Ying Ji8Zhi Wu9Penghui Zeng10Jianwei Zhou11Xufei Feng12Lei Hou13Jue Liu14College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaTembusu virus (TMUV) can induce severe egg drop syndrome in ducks, causing significant economic losses. In this study, the possible origin, genomic epidemiology, and transmission dynamics of TMUV were determined. The time to the most recent common ancestor of TMUV was found to be 1924, earlier than that previously reported. The effective population size of TMUV increased rapidly from 2010 to 2013 and was associated with the diversification of different TMUV clusters. TMUV was classified into three clusters (clusters 1, 2, and 3) based on the envelope (E) protein. Subcluster 2.2, within cluster 2, is the most prevalent, and the occurrence of these mutations is accompanied by changes in the virulence and infectivity of the virus. Two positive selections on codons located in the <i>NS3</i> and <i>NS5</i> genes (591 of NS3 and 883 of NS5) were identified, which might have caused changes in the ability of the virus to replicate. Based on phylogeographic analysis, Malaysia was the most likely country of origin for TMUV, while Shandong Province was the earliest province of origin in China. This study has important implications for understanding TMUV and provides suggestions for its prevention and control.https://www.mdpi.com/1999-4915/14/6/1236Tembusu virusevolutionary originphylodynamicepidemiologyphylogeography |
| spellingShingle | Yongqiu Cui Yang Pan Jinshuo Guo Dedong Wang Xinxin Tong Yongxia Wang Jingyi Li Jie Zhao Ying Ji Zhi Wu Penghui Zeng Jianwei Zhou Xufei Feng Lei Hou Jue Liu The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus Viruses Tembusu virus evolutionary origin phylodynamic epidemiology phylogeography |
| title | The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus |
| title_full | The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus |
| title_fullStr | The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus |
| title_full_unstemmed | The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus |
| title_short | The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus |
| title_sort | evolution genomic epidemiology and transmission dynamics of tembusu virus |
| topic | Tembusu virus evolutionary origin phylodynamic epidemiology phylogeography |
| url | https://www.mdpi.com/1999-4915/14/6/1236 |
| work_keys_str_mv | AT yongqiucui theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT yangpan theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jinshuoguo theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT dedongwang theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT xinxintong theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT yongxiawang theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jingyili theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jiezhao theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT yingji theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT zhiwu theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT penghuizeng theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jianweizhou theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT xufeifeng theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT leihou theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jueliu theevolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT yongqiucui evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT yangpan evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jinshuoguo evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT dedongwang evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT xinxintong evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT yongxiawang evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jingyili evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jiezhao evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT yingji evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT zhiwu evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT penghuizeng evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jianweizhou evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT xufeifeng evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT leihou evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus AT jueliu evolutiongenomicepidemiologyandtransmissiondynamicsoftembusuvirus |