Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature Review
Carcinoma showing thymus-like differentiation (CASTLE) is a rare malignant neoplasm that occurs in the thyroid gland, or head and neck. This tumor arises from either ectopic thymus tissue or remnants of branchial pouches, which retain the potential to differentiate along the thymus line. Clinical pr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-11-01
|
| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X09700208 |
| _version_ | 1818260036781080576 |
|---|---|
| author | Leong-Perng Chan Feng-Yu Chiang Ka-Wo Lee Wen-Rei Kuo |
| author_facet | Leong-Perng Chan Feng-Yu Chiang Ka-Wo Lee Wen-Rei Kuo |
| author_sort | Leong-Perng Chan |
| collection | DOAJ |
| description | Carcinoma showing thymus-like differentiation (CASTLE) is a rare malignant neoplasm that occurs in the thyroid gland, or head and neck. This tumor arises from either ectopic thymus tissue or remnants of branchial pouches, which retain the potential to differentiate along the thymus line. Clinical presentation and imaging can be consistent with a malignant lesion such as thyroid cancer or thymic carcinoma. Immunohistochemical staining with CD5 can differentiate CASTLE from other malignant thyroid neoplasms. A 54-year-old male had initially presented with a painless, left neck mass for 3 months. He underwent left thyroid lobectomy via a median sternotomy approach. Carcinoma showing thymus-like differentiation was the final histopathologic diagnosis. After 36 months of follow-up, no evidence of recurrence was observed. A median sternotomy is an excellent approach for CASTLE with anterior mediastinum involvement. Complete resection is important to improve the long-term survival rate and the locoregional recurrence rate. |
| first_indexed | 2024-12-12T18:24:57Z |
| format | Article |
| id | doaj.art-0ecc994acf95492fbbbe7fef8ed1433d |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-12T18:24:57Z |
| publishDate | 2008-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-0ecc994acf95492fbbbe7fef8ed1433d2022-12-22T00:16:03ZengWileyKaohsiung Journal of Medical Sciences1607-551X2008-11-01241159159710.1016/S1607-551X(09)70020-8Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature ReviewLeong-Perng Chan0Feng-Yu Chiang1Ka-Wo Lee2Wen-Rei Kuo3Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanCarcinoma showing thymus-like differentiation (CASTLE) is a rare malignant neoplasm that occurs in the thyroid gland, or head and neck. This tumor arises from either ectopic thymus tissue or remnants of branchial pouches, which retain the potential to differentiate along the thymus line. Clinical presentation and imaging can be consistent with a malignant lesion such as thyroid cancer or thymic carcinoma. Immunohistochemical staining with CD5 can differentiate CASTLE from other malignant thyroid neoplasms. A 54-year-old male had initially presented with a painless, left neck mass for 3 months. He underwent left thyroid lobectomy via a median sternotomy approach. Carcinoma showing thymus-like differentiation was the final histopathologic diagnosis. After 36 months of follow-up, no evidence of recurrence was observed. A median sternotomy is an excellent approach for CASTLE with anterior mediastinum involvement. Complete resection is important to improve the long-term survival rate and the locoregional recurrence rate.http://www.sciencedirect.com/science/article/pii/S1607551X09700208CASTLEsternotomythymusthyroid gland |
| spellingShingle | Leong-Perng Chan Feng-Yu Chiang Ka-Wo Lee Wen-Rei Kuo Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature Review Kaohsiung Journal of Medical Sciences CASTLE sternotomy thymus thyroid gland |
| title | Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature Review |
| title_full | Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature Review |
| title_fullStr | Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature Review |
| title_full_unstemmed | Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature Review |
| title_short | Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature Review |
| title_sort | carcinoma showing thymus like differentiation castle of thyroid a case report and literature review |
| topic | CASTLE sternotomy thymus thyroid gland |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X09700208 |
| work_keys_str_mv | AT leongperngchan carcinomashowingthymuslikedifferentiationcastleofthyroidacasereportandliteraturereview AT fengyuchiang carcinomashowingthymuslikedifferentiationcastleofthyroidacasereportandliteraturereview AT kawolee carcinomashowingthymuslikedifferentiationcastleofthyroidacasereportandliteraturereview AT wenreikuo carcinomashowingthymuslikedifferentiationcastleofthyroidacasereportandliteraturereview |