IgY antibodies for the immunoprophylaxis and therapy of respiratory infections
Emergence of drug resistance among the causative organisms for respiratory tract infections represents a critical challenge to the global health care community. Further, although vaccination can prevent disease, vaccine development is impeded by several factors. Therefore, novel approaches to treat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1514224 |
| _version_ | 1797677454642380800 |
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| author | Aymn Talat Abbas Sherif Aly El-Kafrawy Sayed Sartaj Sohrab Esam Ibraheem Ahmed Azhar |
| author_facet | Aymn Talat Abbas Sherif Aly El-Kafrawy Sayed Sartaj Sohrab Esam Ibraheem Ahmed Azhar |
| author_sort | Aymn Talat Abbas |
| collection | DOAJ |
| description | Emergence of drug resistance among the causative organisms for respiratory tract infections represents a critical challenge to the global health care community. Further, although vaccination can prevent disease, vaccine development is impeded by several factors. Therefore, novel approaches to treat and manage respiratory infections are urgently needed. Passive immunization represents a possible alternative to meet this need. Immunoglobulin Y antibodies (IgYs) from the yolk of chicken eggs have previously been used against bacterial and viral infections in human and animals. Their advantages include lack of reaction with mammalian Fc receptors, low production cost, and ease of extraction. Compared to mammalian IgGs, they have higher target specificity and greater binding avidity. They also possess remarkable pathogen-neutralizing activity in the respiratory tract and lungs. In this review, we provide an overview of avian IgYs and describe their potential therapeutic applications for the prevention and treatment of respiratory infections. |
| first_indexed | 2024-03-11T22:44:22Z |
| format | Article |
| id | doaj.art-0eccfd9ff01f40bb80479c3f8b674121 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:44:22Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-0eccfd9ff01f40bb80479c3f8b6741212023-09-22T08:38:23ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2019-01-0115126427510.1080/21645515.2018.15142241514224IgY antibodies for the immunoprophylaxis and therapy of respiratory infectionsAymn Talat Abbas0Sherif Aly El-Kafrawy1Sayed Sartaj Sohrab2Esam Ibraheem Ahmed Azhar3King Abdulaziz UniversityKing Abdulaziz UniversityKing Abdulaziz UniversityKing Abdulaziz UniversityEmergence of drug resistance among the causative organisms for respiratory tract infections represents a critical challenge to the global health care community. Further, although vaccination can prevent disease, vaccine development is impeded by several factors. Therefore, novel approaches to treat and manage respiratory infections are urgently needed. Passive immunization represents a possible alternative to meet this need. Immunoglobulin Y antibodies (IgYs) from the yolk of chicken eggs have previously been used against bacterial and viral infections in human and animals. Their advantages include lack of reaction with mammalian Fc receptors, low production cost, and ease of extraction. Compared to mammalian IgGs, they have higher target specificity and greater binding avidity. They also possess remarkable pathogen-neutralizing activity in the respiratory tract and lungs. In this review, we provide an overview of avian IgYs and describe their potential therapeutic applications for the prevention and treatment of respiratory infections.http://dx.doi.org/10.1080/21645515.2018.1514224immunotherapypassive immunizationigyrespiratory infection |
| spellingShingle | Aymn Talat Abbas Sherif Aly El-Kafrawy Sayed Sartaj Sohrab Esam Ibraheem Ahmed Azhar IgY antibodies for the immunoprophylaxis and therapy of respiratory infections Human Vaccines & Immunotherapeutics immunotherapy passive immunization igy respiratory infection |
| title | IgY antibodies for the immunoprophylaxis and therapy of respiratory infections |
| title_full | IgY antibodies for the immunoprophylaxis and therapy of respiratory infections |
| title_fullStr | IgY antibodies for the immunoprophylaxis and therapy of respiratory infections |
| title_full_unstemmed | IgY antibodies for the immunoprophylaxis and therapy of respiratory infections |
| title_short | IgY antibodies for the immunoprophylaxis and therapy of respiratory infections |
| title_sort | igy antibodies for the immunoprophylaxis and therapy of respiratory infections |
| topic | immunotherapy passive immunization igy respiratory infection |
| url | http://dx.doi.org/10.1080/21645515.2018.1514224 |
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