Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study
Abstract Background Lewy body dementia (LBD) ranks second among prevalent neurodegenerative dementias. Previous studies have revealed associations of serum lipid measures with several neurodegenerative diseases. Nevertheless, the potential connection between serum lipids and LBD remains undetermined...
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BMC
2024-02-01
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Series: | Lipids in Health and Disease |
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Online Access: | https://doi.org/10.1186/s12944-024-02032-0 |
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author | Pengdi Liu Jin Liu Yafei Zhang Xin Xing Le Zhou Jianqiang Qu Xianxia Yan |
author_facet | Pengdi Liu Jin Liu Yafei Zhang Xin Xing Le Zhou Jianqiang Qu Xianxia Yan |
author_sort | Pengdi Liu |
collection | DOAJ |
description | Abstract Background Lewy body dementia (LBD) ranks second among prevalent neurodegenerative dementias. Previous studies have revealed associations of serum lipid measures with several neurodegenerative diseases. Nevertheless, the potential connection between serum lipids and LBD remains undetermined. In this study, Mendelian randomization (MR) analyses were carried out to assess the causal relationships of several serum lipid measures with the risk of developing LBD. Methods Genome-wide association study (GWAS) data for serum lipids and LBD in European descent individuals were acquired from publicly available genetic summary data. A series of filtering procedures were conducted to identify the genetic variant candidates that are related to serum lipids, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). The causal effects were primarily determined through inverse-variance weighting (IVW)-based analyses. Results Neither TG (odds ratio [OR] = 1.149; 95% confidence interval [CI], 0.887–1.489; P = 0.293) nor HDL-C (OR = 0.864; 95% CI, 0.718–1.041; P = 0.124) had causal effects on LBD. However, a causal relationship was identified between LDL-C and LBD (OR = 1.343; 95% CI, 1.094–1.649; P = 0.005), which remained significant (OR = 1.237; 95% CI, 1.015–1.508; P = 0.035) following adjustment for HDL-C and TG in multivariable MR. Conclusions Elevated serum LDL-C increases the risk of LBD, while HDL-C and TG have no significant causal effects on LBD. |
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issn | 1476-511X |
language | English |
last_indexed | 2024-03-07T14:43:19Z |
publishDate | 2024-02-01 |
publisher | BMC |
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series | Lipids in Health and Disease |
spelling | doaj.art-0ecd074f3fc449c4985cbf2ab05f5de02024-03-05T20:08:05ZengBMCLipids in Health and Disease1476-511X2024-02-012311810.1186/s12944-024-02032-0Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization studyPengdi Liu0Jin Liu1Yafei Zhang2Xin Xing3Le Zhou4Jianqiang Qu5Xianxia Yan6Department of Neurosurgery, the Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Otolaryngology Head and Neck Surgery, Xijing Hospital of Air Force Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiology, the Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, the Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, the Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, the Second Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Background Lewy body dementia (LBD) ranks second among prevalent neurodegenerative dementias. Previous studies have revealed associations of serum lipid measures with several neurodegenerative diseases. Nevertheless, the potential connection between serum lipids and LBD remains undetermined. In this study, Mendelian randomization (MR) analyses were carried out to assess the causal relationships of several serum lipid measures with the risk of developing LBD. Methods Genome-wide association study (GWAS) data for serum lipids and LBD in European descent individuals were acquired from publicly available genetic summary data. A series of filtering procedures were conducted to identify the genetic variant candidates that are related to serum lipids, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). The causal effects were primarily determined through inverse-variance weighting (IVW)-based analyses. Results Neither TG (odds ratio [OR] = 1.149; 95% confidence interval [CI], 0.887–1.489; P = 0.293) nor HDL-C (OR = 0.864; 95% CI, 0.718–1.041; P = 0.124) had causal effects on LBD. However, a causal relationship was identified between LDL-C and LBD (OR = 1.343; 95% CI, 1.094–1.649; P = 0.005), which remained significant (OR = 1.237; 95% CI, 1.015–1.508; P = 0.035) following adjustment for HDL-C and TG in multivariable MR. Conclusions Elevated serum LDL-C increases the risk of LBD, while HDL-C and TG have no significant causal effects on LBD.https://doi.org/10.1186/s12944-024-02032-0Serum lipidsLewy body dementiaMendelian randomizationCausality |
spellingShingle | Pengdi Liu Jin Liu Yafei Zhang Xin Xing Le Zhou Jianqiang Qu Xianxia Yan Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study Lipids in Health and Disease Serum lipids Lewy body dementia Mendelian randomization Causality |
title | Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study |
title_full | Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study |
title_fullStr | Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study |
title_full_unstemmed | Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study |
title_short | Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study |
title_sort | elevated serum ldl c increases the risk of lewy body dementia a two sample mendelian randomization study |
topic | Serum lipids Lewy body dementia Mendelian randomization Causality |
url | https://doi.org/10.1186/s12944-024-02032-0 |
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