Human T-bet+ B cell development is associated with BTK activity and suppressed by evobrutinib

Human T-bet+ B cell development is associated with BTK activity and suppressed by evobrutinib

Recent clinical trials have shown promising results for the next-generation Bruton’s tyrosine kinase (BTK) inhibitor evobrutinib in the treatment of multiple sclerosis (MS). BTK has a central role in signaling pathways that govern the development of B cells. Whether and how BTK activity shapes B cel...

Bibliografske podrobnosti
Main Authors:	Liza Rijvers, Jamie van Langelaar, Laurens Bogers, Marie-José Melief, Steven C. Koetzier, Katelijn M. Blok, Annet F. Wierenga-Wolf, Helga E. de Vries, Jasper Rip, Odilia B.J. Corneth, Rudi W. Hendriks, Roland Grenningloh, Ursula Boschert, Joost Smolders, Marvin M. van Luijn
Format:	Article
Jezik:	English
Izdano:	American Society for Clinical investigation 2022-08-01
Serija:	JCI Insight
Teme:	Autoimmunity Immunology
Online dostop:	https://doi.org/10.1172/jci.insight.160909

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