Synchronous Primary Parosteal Osteosarcoma and Primary Mediastinal Germ Cell Tumour with Atypical Mycobacterial Infection – A Rare Phenomenon: A Case Report
Mediastinal germ cell tumours are a rare group of extragonadal germ cell tumours with less than 5% prevalence of all germ cell tumours. Primary mediastinal germ cell tumours themselves account for 16-36% of the extragonadal germ cell tumours. Along the spectrum of osteosarcoma, parosteal osteosarc...
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| Format: | Article |
| Language: | English |
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Malaysian Orthopaedic Association
2023-03-01
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| Series: | Malaysian Orthopaedic Journal |
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| Online Access: | http://morthoj.org/2023/v17n1/mediastinal-germ-cell.pdf |
| _version_ | 1797817398965829632 |
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| author | Lim CH Mohamed-Haflah NH Abdullah-Sani MH Loh CK Rahman MR |
| author_facet | Lim CH Mohamed-Haflah NH Abdullah-Sani MH Loh CK Rahman MR |
| author_sort | Lim CH |
| collection | DOAJ |
| description | Mediastinal germ cell tumours are a rare group of extragonadal germ cell tumours with less than 5% prevalence of all germ cell tumours. Primary mediastinal germ cell tumours themselves account for 16-36% of the extragonadal germ cell tumours.
Along the spectrum of osteosarcoma, parosteal osteosarcoma is a well- differentiated surface osteosarcoma with a prevalence of 4% of all osteosarcoma. As such synchronous primary parosteal osteosarcoma and primary mediastinal germ cell tumour are exceedingly rare. This leads to complexity in determining the most appropriate chemotherapy for two different types of tumours and its potential side effects of reduced immunity leading to potential secondary infection. Here we report a case of a 16-year-old boy who presented with synchronous primary osteosarcoma and primary mediastinal germ cell tumour, complicated with atypical mycobacterial infection post-operatively. Additionally, we discuss our choice of chemotherapy and the management of the atypical mycobacterial infection. |
| first_indexed | 2024-03-13T08:53:56Z |
| format | Article |
| id | doaj.art-0ed1208077374617b4794685c1c70a81 |
| institution | Directory Open Access Journal |
| issn | 1985-2533 2232-111X |
| language | English |
| last_indexed | 2024-03-13T08:53:56Z |
| publishDate | 2023-03-01 |
| publisher | Malaysian Orthopaedic Association |
| record_format | Article |
| series | Malaysian Orthopaedic Journal |
| spelling | doaj.art-0ed1208077374617b4794685c1c70a812023-05-29T05:47:45ZengMalaysian Orthopaedic AssociationMalaysian Orthopaedic Journal1985-25332232-111X2023-03-0117118819210.5704/MOJ.2303.023Synchronous Primary Parosteal Osteosarcoma and Primary Mediastinal Germ Cell Tumour with Atypical Mycobacterial Infection – A Rare Phenomenon: A Case ReportLim CH0Mohamed-Haflah NH1Abdullah-Sani MH2Loh CK3Rahman MR4 Department of Orthopaedic and Traumatology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Department of Orthopaedic and Traumatology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Department of Orthopaedic and Traumatology, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Paediatrics, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaMediastinal germ cell tumours are a rare group of extragonadal germ cell tumours with less than 5% prevalence of all germ cell tumours. Primary mediastinal germ cell tumours themselves account for 16-36% of the extragonadal germ cell tumours. Along the spectrum of osteosarcoma, parosteal osteosarcoma is a well- differentiated surface osteosarcoma with a prevalence of 4% of all osteosarcoma. As such synchronous primary parosteal osteosarcoma and primary mediastinal germ cell tumour are exceedingly rare. This leads to complexity in determining the most appropriate chemotherapy for two different types of tumours and its potential side effects of reduced immunity leading to potential secondary infection. Here we report a case of a 16-year-old boy who presented with synchronous primary osteosarcoma and primary mediastinal germ cell tumour, complicated with atypical mycobacterial infection post-operatively. Additionally, we discuss our choice of chemotherapy and the management of the atypical mycobacterial infection.http://morthoj.org/2023/v17n1/mediastinal-germ-cell.pdfgerm cell tumourmediastinalparosteal osteosarcomasynchronoustuberculosis |
| spellingShingle | Lim CH Mohamed-Haflah NH Abdullah-Sani MH Loh CK Rahman MR Synchronous Primary Parosteal Osteosarcoma and Primary Mediastinal Germ Cell Tumour with Atypical Mycobacterial Infection – A Rare Phenomenon: A Case Report Malaysian Orthopaedic Journal germ cell tumour mediastinal parosteal osteosarcoma synchronous tuberculosis |
| title | Synchronous Primary Parosteal Osteosarcoma and Primary Mediastinal Germ Cell Tumour with Atypical Mycobacterial Infection – A Rare Phenomenon: A Case Report |
| title_full | Synchronous Primary Parosteal Osteosarcoma and Primary Mediastinal Germ Cell Tumour with Atypical Mycobacterial Infection – A Rare Phenomenon: A Case Report |
| title_fullStr | Synchronous Primary Parosteal Osteosarcoma and Primary Mediastinal Germ Cell Tumour with Atypical Mycobacterial Infection – A Rare Phenomenon: A Case Report |
| title_full_unstemmed | Synchronous Primary Parosteal Osteosarcoma and Primary Mediastinal Germ Cell Tumour with Atypical Mycobacterial Infection – A Rare Phenomenon: A Case Report |
| title_short | Synchronous Primary Parosteal Osteosarcoma and Primary Mediastinal Germ Cell Tumour with Atypical Mycobacterial Infection – A Rare Phenomenon: A Case Report |
| title_sort | synchronous primary parosteal osteosarcoma and primary mediastinal germ cell tumour with atypical mycobacterial infection a rare phenomenon a case report |
| topic | germ cell tumour mediastinal parosteal osteosarcoma synchronous tuberculosis |
| url | http://morthoj.org/2023/v17n1/mediastinal-germ-cell.pdf |
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