Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease
Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/14/3/153 |
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| author | Saira Rafaqat Sanja Gluscevic Filiz Mercantepe Sana Rafaqat Aleksandra Klisic |
| author_facet | Saira Rafaqat Sanja Gluscevic Filiz Mercantepe Sana Rafaqat Aleksandra Klisic |
| author_sort | Saira Rafaqat |
| collection | DOAJ |
| description | Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results. Further studies are needed to elucidate their beneficial properties in NAFLD treatment. |
| first_indexed | 2024-04-24T18:01:10Z |
| format | Article |
| id | doaj.art-0ed19bff76a948a28cedcbfc452f14a3 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-04-24T18:01:10Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-0ed19bff76a948a28cedcbfc452f14a32024-03-27T13:54:08ZengMDPI AGMetabolites2218-19892024-03-0114315310.3390/metabo14030153Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver DiseaseSaira Rafaqat0Sanja Gluscevic1Filiz Mercantepe2Sana Rafaqat3Aleksandra Klisic4Department of Zoology, Lahore College for Women University, Lahore 54600, PakistanClinical Center of Montenegro, Department for Neurology, 81000 Podgorica, MontenegroDepartment of Endocrinology and Metabolism, Faculty of Medicine, Recep Tayyip Erdogan University, 53010 Rize, TurkeyDepartment of Biotechnology (Human Genetics), Lahore College for Women University, Lahore 54600, PakistanFaculty of Medicine, University of Montenegro, 81000 Podgorica, MontenegroInflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results. Further studies are needed to elucidate their beneficial properties in NAFLD treatment.https://www.mdpi.com/2218-1989/14/3/153non-alcoholic fatty liver diseaseinterleukinsinflammation |
| spellingShingle | Saira Rafaqat Sanja Gluscevic Filiz Mercantepe Sana Rafaqat Aleksandra Klisic Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease Metabolites non-alcoholic fatty liver disease interleukins inflammation |
| title | Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease |
| title_full | Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease |
| title_fullStr | Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease |
| title_short | Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease |
| title_sort | interleukins pathogenesis in non alcoholic fatty liver disease |
| topic | non-alcoholic fatty liver disease interleukins inflammation |
| url | https://www.mdpi.com/2218-1989/14/3/153 |
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