Integrative genomic analysis of the human immune response to influenza vaccination
Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2013-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/00299 |
| _version_ | 1811180652015386624 |
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| author | Luis M Franco Kristine L Bucasas Janet M Wells Diane Niño Xueqing Wang Gladys E Zapata Nancy Arden Alexander Renwick Peng Yu John M Quarles Molly S Bray Robert B Couch John W Belmont Chad A Shaw |
| author_facet | Luis M Franco Kristine L Bucasas Janet M Wells Diane Niño Xueqing Wang Gladys E Zapata Nancy Arden Alexander Renwick Peng Yu John M Quarles Molly S Bray Robert B Couch John W Belmont Chad A Shaw |
| author_sort | Luis M Franco |
| collection | DOAJ |
| description | Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. |
| first_indexed | 2024-04-11T09:05:42Z |
| format | Article |
| id | doaj.art-0ed553e2c2da41cb90e5b8d8ccd3d7c0 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:42Z |
| publishDate | 2013-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0ed553e2c2da41cb90e5b8d8ccd3d7c02022-12-22T04:32:37ZengeLife Sciences Publications LtdeLife2050-084X2013-07-01210.7554/eLife.00299Integrative genomic analysis of the human immune response to influenza vaccinationLuis M Franco0Kristine L Bucasas1Janet M Wells2Diane Niño3Xueqing Wang4Gladys E Zapata5Nancy Arden6Alexander Renwick7Peng Yu8John M Quarles9Molly S Bray10Robert B Couch11John W Belmont12Chad A Shaw13Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Department of Medicine, Baylor College of Medicine, Houston, United StatesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United StatesDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, United StatesDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, United StatesChildren’s Nutrition Research Center, Baylor College of Medicine, Houston, United StatesChildren’s Nutrition Research Center, Baylor College of Medicine, Houston, United StatesDepartment of Microbial and Molecular Pathogenesis, Texas A&M University System Health Science Center, College Station, United StatesInterdepartmental Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, United StatesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United StatesDepartment of Microbial and Molecular Pathogenesis, Texas A&M University System Health Science Center, College Station, United StatesChildren’s Nutrition Research Center, Baylor College of Medicine, Houston, United StatesDepartment of Medicine, Baylor College of Medicine, Houston, United States; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, United StatesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Children’s Nutrition Research Center, Baylor College of Medicine, Houston, United StatesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United StatesIdentification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits.https://elifesciences.org/articles/00299Complex-trait geneticVaccineHuman geneticIntegrative biologySystems biologyeQTL |
| spellingShingle | Luis M Franco Kristine L Bucasas Janet M Wells Diane Niño Xueqing Wang Gladys E Zapata Nancy Arden Alexander Renwick Peng Yu John M Quarles Molly S Bray Robert B Couch John W Belmont Chad A Shaw Integrative genomic analysis of the human immune response to influenza vaccination eLife Complex-trait genetic Vaccine Human genetic Integrative biology Systems biology eQTL |
| title | Integrative genomic analysis of the human immune response to influenza vaccination |
| title_full | Integrative genomic analysis of the human immune response to influenza vaccination |
| title_fullStr | Integrative genomic analysis of the human immune response to influenza vaccination |
| title_full_unstemmed | Integrative genomic analysis of the human immune response to influenza vaccination |
| title_short | Integrative genomic analysis of the human immune response to influenza vaccination |
| title_sort | integrative genomic analysis of the human immune response to influenza vaccination |
| topic | Complex-trait genetic Vaccine Human genetic Integrative biology Systems biology eQTL |
| url | https://elifesciences.org/articles/00299 |
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