<i>N</i>-Acetyl-<span style="font-variant: small-caps">l</span>-phenylalanine Racemization during TBTU Amidation: An In-Depth Study for the Synthesis of Anti-Inflammatory 2-(<i>N</i>-Acetyl)-<span style="font-variant: small-caps">l</span>-phenylalanylamido-2-deoxy-<span style="font-variant: small-caps">d</span>-glucose (NAPA)

<i>N</i>-Acetyl-<span style="font-variant: small-caps">l</span>-phenylalanine Racemization during TBTU Amidation: An In-Depth Study for the Synthesis of Anti-Inflammatory 2-(<i>N</i>-Acetyl)-<span style="font-variant: small-caps">l</span>-phenylalanylamido-2-deoxy-<span style="font-variant: small-caps">d</span>-glucose (NAPA)

A thorough study on the amidation conditions of <i>N</i>-acetyl-<span style="font-variant: small-caps;">l</span>-phenylalanine using TBTU and various bases is reported for the synthesis of 2-(<i>N</i>-acetyl)-<span style="font-variant: small-caps...

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Bibliographic Details
Main Authors: Elisa Sturabotti, Fabrizio Vetica, Giorgia Toscano, Andrea Calcaterra, Andrea Martinelli, Luisa Maria Migneco, Francesca Leonelli
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
racemization
<i>N</i>-acetyl amino acids
coupling
TBTU
pyridine
Online Access:https://www.mdpi.com/1420-3049/28/2/581

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