Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade
Jie Luo, Shuting Chen, Su Min, Lihua Peng Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Abstract: Postoperative residual neuromuscular block is a serious threat which endangers the patient safety. Neostigmine has been the most...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-12-01
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| Series: | Therapeutics and Clinical Risk Management |
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| Online Access: | https://www.dovepress.com/reevaluation-and-update-on-efficacy-and-safety-of-neostigmine-for-reve-peer-reviewed-article-TCRM |
| _version_ | 1819118152269692928 |
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| author | Luo J Chen S Min S Peng L |
| author_facet | Luo J Chen S Min S Peng L |
| author_sort | Luo J |
| collection | DOAJ |
| description | Jie Luo, Shuting Chen, Su Min, Lihua Peng Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Abstract: Postoperative residual neuromuscular block is a serious threat which endangers the patient safety. Neostigmine has been the most commonly used anticholinesterase for the pharmacological reversal of neuromuscular blockade. Although newer agents have been introduced recently, neostigmine has some irreplaceable advantages, including broad-spectrum reversal of all nondepolarizing neuromuscular blocking drugs, low cost, and availability of more related data for clinical practice to refer to. Neostigmine is also noticed to have some drawbacks, such as the inability to reverse profound and deep blockade, potential induction of muscle weakness, cardiovascular adverse effects, and so on. Data on the usage of neostigmine in the geriatric and the pediatric population are still insufficient. Some discrepancies are observed in the results from previous studies which need further investigation. However, recent studies offer some renewed information. Regarding both efficacy and safety, the key for successful reversal of neuromuscular blockade is to use neostigmine “appropriately,” optimizing the dosage and timing of administration under close monitoring. Keywords: postoperative residual neuromuscular block, neuromuscular reversal, anticholinesterase, postanesthesia care, postoperative complication |
| first_indexed | 2024-12-22T05:44:20Z |
| format | Article |
| id | doaj.art-0ed5c0a68ec2456b8fe33919c3759542 |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-22T05:44:20Z |
| publishDate | 2018-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-0ed5c0a68ec2456b8fe33919c37595422022-12-21T18:37:05ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2018-12-01Volume 142397240642926Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockadeLuo JChen SMin SPeng LJie Luo, Shuting Chen, Su Min, Lihua Peng Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Abstract: Postoperative residual neuromuscular block is a serious threat which endangers the patient safety. Neostigmine has been the most commonly used anticholinesterase for the pharmacological reversal of neuromuscular blockade. Although newer agents have been introduced recently, neostigmine has some irreplaceable advantages, including broad-spectrum reversal of all nondepolarizing neuromuscular blocking drugs, low cost, and availability of more related data for clinical practice to refer to. Neostigmine is also noticed to have some drawbacks, such as the inability to reverse profound and deep blockade, potential induction of muscle weakness, cardiovascular adverse effects, and so on. Data on the usage of neostigmine in the geriatric and the pediatric population are still insufficient. Some discrepancies are observed in the results from previous studies which need further investigation. However, recent studies offer some renewed information. Regarding both efficacy and safety, the key for successful reversal of neuromuscular blockade is to use neostigmine “appropriately,” optimizing the dosage and timing of administration under close monitoring. Keywords: postoperative residual neuromuscular block, neuromuscular reversal, anticholinesterase, postanesthesia care, postoperative complicationhttps://www.dovepress.com/reevaluation-and-update-on-efficacy-and-safety-of-neostigmine-for-reve-peer-reviewed-article-TCRMpostoperative residual neuromuscular blockneuromuscular reversalanticholinesterasepostanesthesia carepostoperative complication |
| spellingShingle | Luo J Chen S Min S Peng L Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade Therapeutics and Clinical Risk Management postoperative residual neuromuscular block neuromuscular reversal anticholinesterase postanesthesia care postoperative complication |
| title | Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade |
| title_full | Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade |
| title_fullStr | Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade |
| title_full_unstemmed | Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade |
| title_short | Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade |
| title_sort | reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade |
| topic | postoperative residual neuromuscular block neuromuscular reversal anticholinesterase postanesthesia care postoperative complication |
| url | https://www.dovepress.com/reevaluation-and-update-on-efficacy-and-safety-of-neostigmine-for-reve-peer-reviewed-article-TCRM |
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