Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up Study
Hypertension is a major risk factor for stroke, atherosclerosis, and other cardiovascular diseases, and obesity is a major risk factor for hypertension. The aim of this longitudinal study was to investigate sex differences in the correlations among obesity-related indices and incident hypertension i...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/12/6/972 |
| _version_ | 1797485465120538624 |
|---|---|
| author | Wen-Chi Lee Pei-Yu Wu Jiun-Chi Huang Yi-Chun Tsai Yi-Wen Chiu Szu-Chia Chen Jer-Ming Chang Hung-Chun Chen |
| author_facet | Wen-Chi Lee Pei-Yu Wu Jiun-Chi Huang Yi-Chun Tsai Yi-Wen Chiu Szu-Chia Chen Jer-Ming Chang Hung-Chun Chen |
| author_sort | Wen-Chi Lee |
| collection | DOAJ |
| description | Hypertension is a major risk factor for stroke, atherosclerosis, and other cardiovascular diseases, and obesity is a major risk factor for hypertension. The aim of this longitudinal study was to investigate sex differences in the correlations among obesity-related indices and incident hypertension in a large Taiwanese cohort. We included 21,466 enrollees in the Taiwan Biobank and followed them for 4 years. Of the 21,466 patients enrolled in this study, 6899 (mean age, 49.6 ± 10.9 years) were male and 14,567 (mean age, 49.7 ± 10.0 years) were female. Data on visceral adiposity index (VAI), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), lipid accumulation product (LAP), conicity index (CI), body roundness index (BRI), body mass index (BMI), body adiposity index (BAI), and abdominal volume index (AVI) were collected and analyzed. The results showed that all of the studied obesity-related indices were significantly associated with incident hypertension. Among them, WHtR was the strongest predictor of hypertension in both sexes. In addition, interactions between VAI, LAP, CI, BMI, and AVI with sex on incident hypertension were also statistically significant. CI and AVI were more strongly associated with hypertension in the men than in the women, while VAI, LAP, and BMI were more strongly associated with hypertension in the women. In conclusion, the studied obesity-related indices were found to be predictors of incident hypertension, and there were differences in the associations between the male and female participants. Our findings may imply that reducing body weight may be associated with a lower risk of developing hypertension. |
| first_indexed | 2024-03-09T23:20:09Z |
| format | Article |
| id | doaj.art-0ed80bec53774bde878c02f2fec16dd5 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:20:09Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-0ed80bec53774bde878c02f2fec16dd52023-11-23T17:28:33ZengMDPI AGJournal of Personalized Medicine2075-44262022-06-0112697210.3390/jpm12060972Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up StudyWen-Chi Lee0Pei-Yu Wu1Jiun-Chi Huang2Yi-Chun Tsai3Yi-Wen Chiu4Szu-Chia Chen5Jer-Ming Chang6Hung-Chun Chen7Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanHypertension is a major risk factor for stroke, atherosclerosis, and other cardiovascular diseases, and obesity is a major risk factor for hypertension. The aim of this longitudinal study was to investigate sex differences in the correlations among obesity-related indices and incident hypertension in a large Taiwanese cohort. We included 21,466 enrollees in the Taiwan Biobank and followed them for 4 years. Of the 21,466 patients enrolled in this study, 6899 (mean age, 49.6 ± 10.9 years) were male and 14,567 (mean age, 49.7 ± 10.0 years) were female. Data on visceral adiposity index (VAI), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), lipid accumulation product (LAP), conicity index (CI), body roundness index (BRI), body mass index (BMI), body adiposity index (BAI), and abdominal volume index (AVI) were collected and analyzed. The results showed that all of the studied obesity-related indices were significantly associated with incident hypertension. Among them, WHtR was the strongest predictor of hypertension in both sexes. In addition, interactions between VAI, LAP, CI, BMI, and AVI with sex on incident hypertension were also statistically significant. CI and AVI were more strongly associated with hypertension in the men than in the women, while VAI, LAP, and BMI were more strongly associated with hypertension in the women. In conclusion, the studied obesity-related indices were found to be predictors of incident hypertension, and there were differences in the associations between the male and female participants. Our findings may imply that reducing body weight may be associated with a lower risk of developing hypertension.https://www.mdpi.com/2075-4426/12/6/972obesity-related indexsex differenceincident hypertensionTaiwan Biobankfollow-up |
| spellingShingle | Wen-Chi Lee Pei-Yu Wu Jiun-Chi Huang Yi-Chun Tsai Yi-Wen Chiu Szu-Chia Chen Jer-Ming Chang Hung-Chun Chen Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up Study Journal of Personalized Medicine obesity-related index sex difference incident hypertension Taiwan Biobank follow-up |
| title | Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up Study |
| title_full | Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up Study |
| title_fullStr | Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up Study |
| title_full_unstemmed | Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up Study |
| title_short | Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up Study |
| title_sort | sex difference in the associations among obesity related indices with incident hypertension in a large taiwanese population follow up study |
| topic | obesity-related index sex difference incident hypertension Taiwan Biobank follow-up |
| url | https://www.mdpi.com/2075-4426/12/6/972 |
| work_keys_str_mv | AT wenchilee sexdifferenceintheassociationsamongobesityrelatedindiceswithincidenthypertensioninalargetaiwanesepopulationfollowupstudy AT peiyuwu sexdifferenceintheassociationsamongobesityrelatedindiceswithincidenthypertensioninalargetaiwanesepopulationfollowupstudy AT jiunchihuang sexdifferenceintheassociationsamongobesityrelatedindiceswithincidenthypertensioninalargetaiwanesepopulationfollowupstudy AT yichuntsai sexdifferenceintheassociationsamongobesityrelatedindiceswithincidenthypertensioninalargetaiwanesepopulationfollowupstudy AT yiwenchiu sexdifferenceintheassociationsamongobesityrelatedindiceswithincidenthypertensioninalargetaiwanesepopulationfollowupstudy AT szuchiachen sexdifferenceintheassociationsamongobesityrelatedindiceswithincidenthypertensioninalargetaiwanesepopulationfollowupstudy AT jermingchang sexdifferenceintheassociationsamongobesityrelatedindiceswithincidenthypertensioninalargetaiwanesepopulationfollowupstudy AT hungchunchen sexdifferenceintheassociationsamongobesityrelatedindiceswithincidenthypertensioninalargetaiwanesepopulationfollowupstudy |