Cellular Redox State Acts as Switch to Determine the Direction of NNT-Catalyzed Reaction in Cystic Fibrosis Cells

Cellular Redox State Acts as Switch to Determine the Direction of NNT-Catalyzed Reaction in Cystic Fibrosis Cells

The redox states of NAD and NADP are linked to each other in the mitochondria thanks to the enzyme nicotinamide nucleotide transhydrogenase (NNT) which, by utilizing the mitochondrial membrane potential (mΔΨ), catalyzes the transfer of redox potential between these two coenzymes, reducing one at the...

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Bibliographic Details
Main Authors:	Maria Favia, Anna Atlante
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	International Journal of Molecular Sciences
Subjects:	nicotinamide nucleotide transhydrogenase cystic fibrosis mitochondria glucose-6-phosphate dehydrogenase NADPH antioxidant
Online Access:	https://www.mdpi.com/1422-0067/22/2/967

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