A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells

A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Our recent studies have shown that the diamine-(PEG)ylated oleanolic acid (OADP) has strong anti-tumor effects in HCCs. In this study, we evaluated the anti-tumor mechanisms of OADP in the HepG2 HCC cell line. The cytotoxicity r...

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Bibliographic Details
Main Authors: Fatin Jannus, Marta Medina-O’Donnell, Francisco Rivas, Luis Díaz-Ruiz, Eva E. Rufino-Palomares, José A. Lupiáñez, Andrés Parra, Fernando J. Reyes-Zurita
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
triterpenes
oleanolic acid
(PEG)ylated oleanolic acid
extrinsic apoptotic pathway
anti-tumor mechanisms
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2218-273X/10/10/1375

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