Circ_0083964 knockdown impedes rheumatoid arthritis progression via the miR-204-5p-dependent regulation of YY1
Highlights 1. Circ_0083964 was overexpressed in RA synovial tissues and RA-FLSs. 2. Circ_0083964 inhibition repressed cell growth, invasion, migration and inflammatory response in RA-FLSs. 3. Circ_0083964 functioned as a molecular sponge of miR-204-5p. 4. YY1 acted as a miR-204-5p target.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-022-03353-5 |
| Summary: | Highlights 1. Circ_0083964 was overexpressed in RA synovial tissues and RA-FLSs. 2. Circ_0083964 inhibition repressed cell growth, invasion, migration and inflammatory response in RA-FLSs. 3. Circ_0083964 functioned as a molecular sponge of miR-204-5p. 4. YY1 acted as a miR-204-5p target. |
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| ISSN: | 1749-799X |