The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism
Betula platyphylla var. japonica (Betulaceae) has been used traditionally in Asian countries for the treatment of inflammatory diseases. A recent study has reported a phenolic compound, platyphylloside from B. platyphylla, that shows inhibition on adipocyte differentiation and induces lipolysis in 3...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14756366.2018.1491846 |
| _version_ | 1818334179261153280 |
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| author | Joo Young Huh Seulah Lee Eun-Bi Ma Hee Jeong Eom Jiwon Baek Yoon-Joo Ko Ki Hyun Kim |
| author_facet | Joo Young Huh Seulah Lee Eun-Bi Ma Hee Jeong Eom Jiwon Baek Yoon-Joo Ko Ki Hyun Kim |
| author_sort | Joo Young Huh |
| collection | DOAJ |
| description | Betula platyphylla var. japonica (Betulaceae) has been used traditionally in Asian countries for the treatment of inflammatory diseases. A recent study has reported a phenolic compound, platyphylloside from B. platyphylla, that shows inhibition on adipocyte differentiation and induces lipolysis in 3T3-L1 cells. Based on this finding, we conducted phytochemical analysis of the EtOH extract of the bark of B. platyphylla var. japonica, which resulted in the isolation of phenolic glycosides (1–4). Treatment of the isolated compounds (1–4) during adipocyte differentiation of 3T3-L1 mouse adipocytes resulted in dose-dependent inhibition of adipogenesis. In mature adipocytes, arylbutanoid glycosides (2–4) induced lipolysis related genes HSL and ATGL, whereas catechin glycoside (1) had no effect. Additionally, arylbutanoid glycosides (2–4) also induced GLUT4 and adiponectin mRNA expression, indicating improvement in insulin signaling. This suggests that the isolates from B. platyphylla var. japonica exert benefial effects in regulation of adipocyte differentiation as well as adipocyte metabolism. |
| first_indexed | 2024-12-13T14:03:25Z |
| format | Article |
| id | doaj.art-0ed95edd25d84552bd426d7f0f72fd56 |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2024-12-13T14:03:25Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-0ed95edd25d84552bd426d7f0f72fd562022-12-21T23:42:39ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742018-01-013311167117310.1080/14756366.2018.14918461491846The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolismJoo Young Huh0Seulah Lee1Eun-Bi Ma2Hee Jeong Eom3Jiwon Baek4Yoon-Joo Ko5Ki Hyun Kim6Chonnam National UniversitySungkyunkwan UniversityChonnam National UniversitySungkyunkwan UniversitySungkyunkwan UniversityNational Center for Inter-University Research Facilities (NCIRF), Seoul National UniversitySungkyunkwan UniversityBetula platyphylla var. japonica (Betulaceae) has been used traditionally in Asian countries for the treatment of inflammatory diseases. A recent study has reported a phenolic compound, platyphylloside from B. platyphylla, that shows inhibition on adipocyte differentiation and induces lipolysis in 3T3-L1 cells. Based on this finding, we conducted phytochemical analysis of the EtOH extract of the bark of B. platyphylla var. japonica, which resulted in the isolation of phenolic glycosides (1–4). Treatment of the isolated compounds (1–4) during adipocyte differentiation of 3T3-L1 mouse adipocytes resulted in dose-dependent inhibition of adipogenesis. In mature adipocytes, arylbutanoid glycosides (2–4) induced lipolysis related genes HSL and ATGL, whereas catechin glycoside (1) had no effect. Additionally, arylbutanoid glycosides (2–4) also induced GLUT4 and adiponectin mRNA expression, indicating improvement in insulin signaling. This suggests that the isolates from B. platyphylla var. japonica exert benefial effects in regulation of adipocyte differentiation as well as adipocyte metabolism.http://dx.doi.org/10.1080/14756366.2018.1491846Betula platyphylla var. japonicacatechin glycosidephenolic glycosideadipocyte differentiationmature adipocyte metabolism |
| spellingShingle | Joo Young Huh Seulah Lee Eun-Bi Ma Hee Jeong Eom Jiwon Baek Yoon-Joo Ko Ki Hyun Kim The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism Journal of Enzyme Inhibition and Medicinal Chemistry Betula platyphylla var. japonica catechin glycoside phenolic glycoside adipocyte differentiation mature adipocyte metabolism |
| title | The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism |
| title_full | The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism |
| title_fullStr | The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism |
| title_full_unstemmed | The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism |
| title_short | The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism |
| title_sort | effects of phenolic glycosides from betula platyphylla var japonica on adipocyte differentiation and mature adipocyte metabolism |
| topic | Betula platyphylla var. japonica catechin glycoside phenolic glycoside adipocyte differentiation mature adipocyte metabolism |
| url | http://dx.doi.org/10.1080/14756366.2018.1491846 |
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