Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel
Dana Shalmon,1 Joel L Cohen,2 Marina Landau,3 Ines Verner,4 Eli Sprecher,1,5 Ofir Artzi1 1Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 2AboutSkin Dermatology and AboutSkin Research, Greenwood and Lone Tree, CO, USA; 3Private Practice, Herzliya, Israel; 4Verner Clini...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-05-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/management-patterns-of-delayed-inflammatory-reactions-to-hyaluronic-ac-peer-reviewed-article-CCID |
| _version_ | 1819207568487088128 |
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| author | Shalmon D Cohen JL Landau M Verner I Sprecher E Artzi O |
| author_facet | Shalmon D Cohen JL Landau M Verner I Sprecher E Artzi O |
| author_sort | Shalmon D |
| collection | DOAJ |
| description | Dana Shalmon,1 Joel L Cohen,2 Marina Landau,3 Ines Verner,4 Eli Sprecher,1,5 Ofir Artzi1 1Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 2AboutSkin Dermatology and AboutSkin Research, Greenwood and Lone Tree, CO, USA; 3Private Practice, Herzliya, Israel; 4Verner Clinic Tel Aviv, University of Rome “Guglielmo Marconi”, Israel, Italy; 5Department of Human Molecular Genetics & Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelCorrespondence: Ofir Artzi Email ofira@tlvmc.gov.ilBackground: Over the past few decades, soft tissue augmentation is ever-increasing, specifically hyaluronic acid (HA)-based filler injections. As the number of these procedures have risen, so have the adverse reactions. Delayed-type inflammatory reactions (DIRs) secondary to tissue fillers are typically classified according to the time of appearance post-procedure and have various presentations including nodules, abscesses, edema, and discoloration. Currently, the treatment of these complications varies among physicians.Objective: The aim of this study was to assess the knowledge and experience of practitioners in Israel who inject HA-based tissue fillers with respect to the management of late-onset procedural complications.Materials and Methods: A survey regarding management and treatment of late-onset inflammatory reactions was sent to 1120 physicians and dentists in Israel who practice tissue filler injections.Results: Three hundred thirty-four out of the 1120 practitioners replied to the questionnaire. The majority of respondents were dentists (group A) comprising 31% of all respondents. Group B accounted for 31% of injectors and consisted of dermatologists (19%) and plastic surgeons (12%), and group C (38%) accounted for all other practitioners; 48.2% of all injectors indicated that they have not previously encountered a DIR, whereas 11.4% responded that they have encountered more than 5 DIRs. In order to assess treatment management, we presented the injectors with a simulatory case of a woman with a late-onset complication. Most injectors referred the patient to the emergency department. When asked to establish a treatment plan, the majority of practitioners prescribed short-term oral steroids, ie, prednisone (35.3%). A limited number of patients were treated with intra-lesional hyaluronidase (31.4%) injection as only 34% of injectors kept hyaluronidase at their clinic.Conclusion: The varied approach regarding the management of delayed type reactions to HA-based filler injections, reflected in our study, illustrates the existing ambivalence in the current literature regarding the management and therapy of late-onset complications.Keywords: cosmetic techniques, dermal fillers/adverse effects, hyaluronic acid/adverse effects, delayed reaction, nodules, filler, hypersensitivity |
| first_indexed | 2024-12-23T05:25:34Z |
| format | Article |
| id | doaj.art-0edc8b10320f4986a13681c92fbeba80 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-23T05:25:34Z |
| publishDate | 2020-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-0edc8b10320f4986a13681c92fbeba802022-12-21T17:58:36ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152020-05-01Volume 1334534953617Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in IsraelShalmon DCohen JLLandau MVerner ISprecher EArtzi ODana Shalmon,1 Joel L Cohen,2 Marina Landau,3 Ines Verner,4 Eli Sprecher,1,5 Ofir Artzi1 1Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 2AboutSkin Dermatology and AboutSkin Research, Greenwood and Lone Tree, CO, USA; 3Private Practice, Herzliya, Israel; 4Verner Clinic Tel Aviv, University of Rome “Guglielmo Marconi”, Israel, Italy; 5Department of Human Molecular Genetics & Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelCorrespondence: Ofir Artzi Email ofira@tlvmc.gov.ilBackground: Over the past few decades, soft tissue augmentation is ever-increasing, specifically hyaluronic acid (HA)-based filler injections. As the number of these procedures have risen, so have the adverse reactions. Delayed-type inflammatory reactions (DIRs) secondary to tissue fillers are typically classified according to the time of appearance post-procedure and have various presentations including nodules, abscesses, edema, and discoloration. Currently, the treatment of these complications varies among physicians.Objective: The aim of this study was to assess the knowledge and experience of practitioners in Israel who inject HA-based tissue fillers with respect to the management of late-onset procedural complications.Materials and Methods: A survey regarding management and treatment of late-onset inflammatory reactions was sent to 1120 physicians and dentists in Israel who practice tissue filler injections.Results: Three hundred thirty-four out of the 1120 practitioners replied to the questionnaire. The majority of respondents were dentists (group A) comprising 31% of all respondents. Group B accounted for 31% of injectors and consisted of dermatologists (19%) and plastic surgeons (12%), and group C (38%) accounted for all other practitioners; 48.2% of all injectors indicated that they have not previously encountered a DIR, whereas 11.4% responded that they have encountered more than 5 DIRs. In order to assess treatment management, we presented the injectors with a simulatory case of a woman with a late-onset complication. Most injectors referred the patient to the emergency department. When asked to establish a treatment plan, the majority of practitioners prescribed short-term oral steroids, ie, prednisone (35.3%). A limited number of patients were treated with intra-lesional hyaluronidase (31.4%) injection as only 34% of injectors kept hyaluronidase at their clinic.Conclusion: The varied approach regarding the management of delayed type reactions to HA-based filler injections, reflected in our study, illustrates the existing ambivalence in the current literature regarding the management and therapy of late-onset complications.Keywords: cosmetic techniques, dermal fillers/adverse effects, hyaluronic acid/adverse effects, delayed reaction, nodules, filler, hypersensitivityhttps://www.dovepress.com/management-patterns-of-delayed-inflammatory-reactions-to-hyaluronic-ac-peer-reviewed-article-CCIDdelayed reactionnoduleshyaluronic acidfillerhypersensitivity |
| spellingShingle | Shalmon D Cohen JL Landau M Verner I Sprecher E Artzi O Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel Clinical, Cosmetic and Investigational Dermatology delayed reaction nodules hyaluronic acid filler hypersensitivity |
| title | Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel |
| title_full | Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel |
| title_fullStr | Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel |
| title_full_unstemmed | Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel |
| title_short | Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel |
| title_sort | management patterns of delayed inflammatory reactions to hyaluronic acid dermal fillers an online survey in israel |
| topic | delayed reaction nodules hyaluronic acid filler hypersensitivity |
| url | https://www.dovepress.com/management-patterns-of-delayed-inflammatory-reactions-to-hyaluronic-ac-peer-reviewed-article-CCID |
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