Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China
Non-O1/non-O139 Vibrio cholerae (NOVC) causes various illnesses ranging in severity from mild to life-threatening but were ignored previously. Knowledge of the NOVC infection, particularly bacteremia, is limited because of its rarity. Here we first retrospectively reported the demographic, clinical...
| প্রধান লেখক: | , , , , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-07-01
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| মালা: | Biomolecules & Biomedicine |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8745 |
| _version_ | 1827317491542523904 |
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| author | Yu-Han Xiang Qin-Qin Hu Yan Liu Rui Sheng Jie Wang Wen-Jing Li Jian Shi Xue Li Shu-Hua Lu |
| author_facet | Yu-Han Xiang Qin-Qin Hu Yan Liu Rui Sheng Jie Wang Wen-Jing Li Jian Shi Xue Li Shu-Hua Lu |
| author_sort | Yu-Han Xiang |
| collection | DOAJ |
| description |
Non-O1/non-O139 Vibrio cholerae (NOVC) causes various illnesses ranging in severity from mild to life-threatening but were ignored previously. Knowledge of the NOVC infection, particularly bacteremia, is limited because of its rarity. Here we first retrospectively reported the demographic, clinical, and therapy characteristics of patients with NOVC infection. Isolated NOVC stains were identified by a series of biochemical, mass spectrometry (MS), and serum agglutination tests. The results of 11 patients with NOVC infection (including 8 with bacteremia) with a median age of 68 years were included in this report. Most isolated NOVC strains had antibiotic susceptibility. Patients with NOVC-positive were distributed in various departments, most occurring in gastroenterology (6 cases). Hepatic disease was the most common comorbid disease, followed by diabetes (3 cases) and biliary tract disease (3 cases). Two cases were previously healthy. The most common symptom at presentation was fever. All patients presented with abnormal changes in hematology and inflammatory parameters. Cephalosporins were the most frequently used antibiotics. Ten patients had a favorable outcome after treatment; one died from complicated underlying diseases. In summary, we recommend the timely identification of NOVC strains using MALDI-TOF-MS. The suspicion of NOVC bacteremia cannot be ruled out regardless of the host’s immune status. An alternative therapeutic regimen for this infection may be β-lactam antibiotics or combined with β-lactamase inhibitors. Regardless, the specific therapeutic regimen should be based on the antibiogram data.
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| first_indexed | 2024-04-24T23:39:44Z |
| format | Article |
| id | doaj.art-0edef393d2ec4e8397bbfb33fedcf263 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:44Z |
| publishDate | 2023-07-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-0edef393d2ec4e8397bbfb33fedcf2632024-03-15T13:22:32ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-07-0123410.17305/bb.2022.8745Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in ChinaYu-Han Xiang0https://orcid.org/0000-0002-0202-7042Qin-Qin Hu1https://orcid.org/0000-0001-7316-1575Yan Liu2https://orcid.org/0000-0003-3001-1512Rui Sheng3https://orcid.org/0000-0002-0772-1439Jie Wang4Wen-Jing Li5https://orcid.org/0000-0002-5839-524XJian Shi6Xue Li7Shu-Hua Lu8https://orcid.org/0000-0003-3099-2461Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, ChinaNursing Department, Affiliated Hospital of Jining Medical University, Jining, ChinaClinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, ChinaClinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, ChinaClinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, ChinaSchool of Clinical Medicine, Jining Medical University, Jining, ChinaSchool of Clinical Medicine, Jining Medical University, Jining, ChinaSchool of Clinical Medicine, Jining Medical University, Jining, ChinaClinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, China Non-O1/non-O139 Vibrio cholerae (NOVC) causes various illnesses ranging in severity from mild to life-threatening but were ignored previously. Knowledge of the NOVC infection, particularly bacteremia, is limited because of its rarity. Here we first retrospectively reported the demographic, clinical, and therapy characteristics of patients with NOVC infection. Isolated NOVC stains were identified by a series of biochemical, mass spectrometry (MS), and serum agglutination tests. The results of 11 patients with NOVC infection (including 8 with bacteremia) with a median age of 68 years were included in this report. Most isolated NOVC strains had antibiotic susceptibility. Patients with NOVC-positive were distributed in various departments, most occurring in gastroenterology (6 cases). Hepatic disease was the most common comorbid disease, followed by diabetes (3 cases) and biliary tract disease (3 cases). Two cases were previously healthy. The most common symptom at presentation was fever. All patients presented with abnormal changes in hematology and inflammatory parameters. Cephalosporins were the most frequently used antibiotics. Ten patients had a favorable outcome after treatment; one died from complicated underlying diseases. In summary, we recommend the timely identification of NOVC strains using MALDI-TOF-MS. The suspicion of NOVC bacteremia cannot be ruled out regardless of the host’s immune status. An alternative therapeutic regimen for this infection may be β-lactam antibiotics or combined with β-lactamase inhibitors. Regardless, the specific therapeutic regimen should be based on the antibiogram data. https://www.bjbms.org/ojs/index.php/bjbms/article/view/8745Non-O1/non-O139 Vibrio choleraeVibrio choleraeinfectionbacteremiaantimicrobial susceptibility |
| spellingShingle | Yu-Han Xiang Qin-Qin Hu Yan Liu Rui Sheng Jie Wang Wen-Jing Li Jian Shi Xue Li Shu-Hua Lu Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China Biomolecules & Biomedicine Non-O1/non-O139 Vibrio cholerae Vibrio cholerae infection bacteremia antimicrobial susceptibility |
| title | Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China |
| title_full | Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China |
| title_fullStr | Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China |
| title_full_unstemmed | Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China |
| title_short | Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China |
| title_sort | etiology and clinical features of non o1 non o139 vibrio cholerae infection in an inland city in china |
| topic | Non-O1/non-O139 Vibrio cholerae Vibrio cholerae infection bacteremia antimicrobial susceptibility |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8745 |
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