An Equivocal SCC Lesion—Antiepileptic-Induced CLOCC
We present a case of a woman who reported to the emergency unit due to recurrent episodes of severe headache and collapse. MRI examination revealed no relevant findings apart from small meningioma of the right parietal region. The patient was diagnosed with epilepsy and received outpatient treatment...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/12/3/384 |
| _version_ | 1797472493726859264 |
|---|---|
| author | Maryla Kuczyńska Monika Zbroja Weronika Cyranka Izabela Halczuk Ewa Kopyto Iwona Halczuk Anna Drelich-Zbroja |
| author_facet | Maryla Kuczyńska Monika Zbroja Weronika Cyranka Izabela Halczuk Ewa Kopyto Iwona Halczuk Anna Drelich-Zbroja |
| author_sort | Maryla Kuczyńska |
| collection | DOAJ |
| description | We present a case of a woman who reported to the emergency unit due to recurrent episodes of severe headache and collapse. MRI examination revealed no relevant findings apart from small meningioma of the right parietal region. The patient was diagnosed with epilepsy and received outpatient treatment, which was changed due to poor toleration. A follow-up MRI was performed which revealed an isolated, focal lesion of the splenium of the corpus callosum. The patient underwent extensive laboratory testing and antiseizure medications were started again. Another MRI indicated substantial regression of the splenium of the corpus callosum (SCC) lesion. Both the complete clinical image and results of the diagnostic evaluation spoke in favor of cytotoxicity of the corpus callosum associated with anti-epileptic drug treatment. Pathologies involving the corpus callosum include congenital, demyelination, infection, neoplasm, trauma and vascular changes. Isolated, non-specific lesions of the splenium of corpus callosum usually indicate multiple sclerosis; however, other pathologies should be considered. Anti-epileptic drugs may evoke cytotoxic lesions of the corpus callosum (CLOCCs). |
| first_indexed | 2024-03-09T20:03:30Z |
| format | Article |
| id | doaj.art-0edf672b9b154c10af1e0ea934e48b47 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T20:03:30Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-0edf672b9b154c10af1e0ea934e48b472023-11-24T00:38:15ZengMDPI AGBrain Sciences2076-34252022-03-0112338410.3390/brainsci12030384An Equivocal SCC Lesion—Antiepileptic-Induced CLOCCMaryla Kuczyńska0Monika Zbroja1Weronika Cyranka2Izabela Halczuk3Ewa Kopyto4Iwona Halczuk5Anna Drelich-Zbroja6Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-059 Lublin, PolandStudents’ Scientific Society at the Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-059 Lublin, PolandStudents’ Scientific Society at the Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-059 Lublin, PolandStudents’ Scientific Society at the Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-059 Lublin, PolandStudents’ Scientific Society at the Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-059 Lublin, PolandDepartment of Neurology, Medical University of Lublin, 20-059 Lublin, PolandDepartment of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-059 Lublin, PolandWe present a case of a woman who reported to the emergency unit due to recurrent episodes of severe headache and collapse. MRI examination revealed no relevant findings apart from small meningioma of the right parietal region. The patient was diagnosed with epilepsy and received outpatient treatment, which was changed due to poor toleration. A follow-up MRI was performed which revealed an isolated, focal lesion of the splenium of the corpus callosum. The patient underwent extensive laboratory testing and antiseizure medications were started again. Another MRI indicated substantial regression of the splenium of the corpus callosum (SCC) lesion. Both the complete clinical image and results of the diagnostic evaluation spoke in favor of cytotoxicity of the corpus callosum associated with anti-epileptic drug treatment. Pathologies involving the corpus callosum include congenital, demyelination, infection, neoplasm, trauma and vascular changes. Isolated, non-specific lesions of the splenium of corpus callosum usually indicate multiple sclerosis; however, other pathologies should be considered. Anti-epileptic drugs may evoke cytotoxic lesions of the corpus callosum (CLOCCs).https://www.mdpi.com/2076-3425/12/3/384corpus callosumspleniummagnetic resonance imagingcytotoxic edemaepilepsy |
| spellingShingle | Maryla Kuczyńska Monika Zbroja Weronika Cyranka Izabela Halczuk Ewa Kopyto Iwona Halczuk Anna Drelich-Zbroja An Equivocal SCC Lesion—Antiepileptic-Induced CLOCC Brain Sciences corpus callosum splenium magnetic resonance imaging cytotoxic edema epilepsy |
| title | An Equivocal SCC Lesion—Antiepileptic-Induced CLOCC |
| title_full | An Equivocal SCC Lesion—Antiepileptic-Induced CLOCC |
| title_fullStr | An Equivocal SCC Lesion—Antiepileptic-Induced CLOCC |
| title_full_unstemmed | An Equivocal SCC Lesion—Antiepileptic-Induced CLOCC |
| title_short | An Equivocal SCC Lesion—Antiepileptic-Induced CLOCC |
| title_sort | equivocal scc lesion antiepileptic induced clocc |
| topic | corpus callosum splenium magnetic resonance imaging cytotoxic edema epilepsy |
| url | https://www.mdpi.com/2076-3425/12/3/384 |
| work_keys_str_mv | AT marylakuczynska anequivocalscclesionantiepilepticinducedclocc AT monikazbroja anequivocalscclesionantiepilepticinducedclocc AT weronikacyranka anequivocalscclesionantiepilepticinducedclocc AT izabelahalczuk anequivocalscclesionantiepilepticinducedclocc AT ewakopyto anequivocalscclesionantiepilepticinducedclocc AT iwonahalczuk anequivocalscclesionantiepilepticinducedclocc AT annadrelichzbroja anequivocalscclesionantiepilepticinducedclocc AT marylakuczynska equivocalscclesionantiepilepticinducedclocc AT monikazbroja equivocalscclesionantiepilepticinducedclocc AT weronikacyranka equivocalscclesionantiepilepticinducedclocc AT izabelahalczuk equivocalscclesionantiepilepticinducedclocc AT ewakopyto equivocalscclesionantiepilepticinducedclocc AT iwonahalczuk equivocalscclesionantiepilepticinducedclocc AT annadrelichzbroja equivocalscclesionantiepilepticinducedclocc |