Comparison of Stored Umbilical Cord Blood and Adult Donor Blood: Transfusion Feasibility
OBJECTIVE: This study aimed to compare the storage properties of red blood cell (RBC) concentrates of umbilical cord blood (UCB) and adult donor blood (ADB), and to evaluate the feasibility of UCB-RBC concentrate as an autologous source for blood transfusion in very low birth weight (VLBW) preterm n...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2012-08-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-94547 |
| _version_ | 1797909159253901312 |
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| author | Rola Sahyoun-tokan Saadet Arsan Ömer Erdeve Nuri Solaz Aslıhan Avcı Serenay Elgün-ülkar Elif Gülyapar Zeynep Üstünyurt Zeynep Bıyıklı Sabri Kemahlı |
| author_facet | Rola Sahyoun-tokan Saadet Arsan Ömer Erdeve Nuri Solaz Aslıhan Avcı Serenay Elgün-ülkar Elif Gülyapar Zeynep Üstünyurt Zeynep Bıyıklı Sabri Kemahlı |
| author_sort | Rola Sahyoun-tokan |
| collection | DOAJ |
| description | OBJECTIVE: This study aimed to compare the storage properties of red blood cell (RBC) concentrates of umbilical cord blood (UCB) and adult donor blood (ADB), and to evaluate the feasibility of UCB-RBC concentrate as an autologous source for blood transfusion in very low birth weight (VLBW) preterm neonates. METHODS: In all, 30 newborn (10 preterm, 20 full term) UCB and 31 ADB units were collected. RBC concentrates were stored and compared with regard to pH, potassium (K+), 2,3-biphosphoglycerate (2-3-BPG), adenosine tri-phosphate (ATP), plasma Hb, and bacterial contamination on d 1, 21, and 35 of storage. RESULTS: The K+ level increased with time and differed significantly between storage d 1 and 21, and between storage d 1 and 35 in both the UCB and ADB units. Initial and d 21 K+ levels were higher in the UCB units than in the ADB units. The 2,3-BPG level did not differ significantly between the UCB-PRC and ADB-PRC samples. After 35 d of storage both UCB-PRC and ADB-PRC samples exhibited significant differences from the initial free Hb, intracellular ATP, and pH values. Significant differences in intracellular ATP and pH were also observed between the UCB-PRC and ADB-PRC samples. CONCLUSION: The volume of harvested and prepared UCB-PRC can be used for some of the blood transfusions required during the neonatal period and thus may decrease the number of allogeneic transfusions, especially in preterm newborns. The hematological and biochemical changes that occurred in UCB during storage were comparable with those observed in ADB, and do not pose a risk to the immature metabolism of neonates. UCB-RPC prepared and stored under standard conditions can be a safe alternative RBC source for transfusions in VLBW newborns. |
| first_indexed | 2024-04-10T11:04:01Z |
| format | Article |
| id | doaj.art-0ee3747f071c4c4d8cf680cb3d2d5900 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:04:01Z |
| publishDate | 2012-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-0ee3747f071c4c4d8cf680cb3d2d59002023-02-15T16:19:31ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632012-08-0129323324110.5505/tjh.2012.94547TJH-94547Comparison of Stored Umbilical Cord Blood and Adult Donor Blood: Transfusion FeasibilityRola Sahyoun-tokan0Saadet Arsan1Ömer Erdeve2Nuri Solaz3Aslıhan Avcı4Serenay Elgün-ülkar5Elif Gülyapar6Zeynep Üstünyurt7Zeynep Bıyıklı8Sabri Kemahlı9Ankara University, Faculty Of Medicine, Department Of Pediatrics, AnkaraAnkara University, Faculty Of Medicine, Department Of Pediatrics, Division Of Neonatology, Ankara, TurkeyAnkara University, Faculty Of Medicine, Department Of Pediatrics, Division Of Neonatology, Ankara, TurkeyAnkara University, Faculty Of Medicine, Serpil Akdağ Blood Center, Ankara, TurkeyAnkara University, Faculty Of Medicine, Department Of Biochemistry, Ankara, TurkeyAnkara University, Faculty Of Medicine, Department Of Biochemistry, Ankara, TurkeyDr. Zekai Tahir Burak Women's Hospital, Ankara, TurkeyDr. Zekai Tahir Burak Women's Hospital, Ankara, TurkeyAnkara University, Faculty Of Medicine, Department Of Biostatistics, Ankara, TurkeyAnkara University, Faculty Of Medicine, Department Of Pediatrics, Division Of Pediatric Hematology, Ankara, TurkeyOBJECTIVE: This study aimed to compare the storage properties of red blood cell (RBC) concentrates of umbilical cord blood (UCB) and adult donor blood (ADB), and to evaluate the feasibility of UCB-RBC concentrate as an autologous source for blood transfusion in very low birth weight (VLBW) preterm neonates. METHODS: In all, 30 newborn (10 preterm, 20 full term) UCB and 31 ADB units were collected. RBC concentrates were stored and compared with regard to pH, potassium (K+), 2,3-biphosphoglycerate (2-3-BPG), adenosine tri-phosphate (ATP), plasma Hb, and bacterial contamination on d 1, 21, and 35 of storage. RESULTS: The K+ level increased with time and differed significantly between storage d 1 and 21, and between storage d 1 and 35 in both the UCB and ADB units. Initial and d 21 K+ levels were higher in the UCB units than in the ADB units. The 2,3-BPG level did not differ significantly between the UCB-PRC and ADB-PRC samples. After 35 d of storage both UCB-PRC and ADB-PRC samples exhibited significant differences from the initial free Hb, intracellular ATP, and pH values. Significant differences in intracellular ATP and pH were also observed between the UCB-PRC and ADB-PRC samples. CONCLUSION: The volume of harvested and prepared UCB-PRC can be used for some of the blood transfusions required during the neonatal period and thus may decrease the number of allogeneic transfusions, especially in preterm newborns. The hematological and biochemical changes that occurred in UCB during storage were comparable with those observed in ADB, and do not pose a risk to the immature metabolism of neonates. UCB-RPC prepared and stored under standard conditions can be a safe alternative RBC source for transfusions in VLBW newborns.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-94547transfusionnewbornvlbw pretermumbilical cord bloodblood storage |
| spellingShingle | Rola Sahyoun-tokan Saadet Arsan Ömer Erdeve Nuri Solaz Aslıhan Avcı Serenay Elgün-ülkar Elif Gülyapar Zeynep Üstünyurt Zeynep Bıyıklı Sabri Kemahlı Comparison of Stored Umbilical Cord Blood and Adult Donor Blood: Transfusion Feasibility Turkish Journal of Hematology transfusion newborn vlbw preterm umbilical cord blood blood storage |
| title | Comparison of Stored Umbilical Cord Blood and Adult Donor Blood: Transfusion Feasibility |
| title_full | Comparison of Stored Umbilical Cord Blood and Adult Donor Blood: Transfusion Feasibility |
| title_fullStr | Comparison of Stored Umbilical Cord Blood and Adult Donor Blood: Transfusion Feasibility |
| title_full_unstemmed | Comparison of Stored Umbilical Cord Blood and Adult Donor Blood: Transfusion Feasibility |
| title_short | Comparison of Stored Umbilical Cord Blood and Adult Donor Blood: Transfusion Feasibility |
| title_sort | comparison of stored umbilical cord blood and adult donor blood transfusion feasibility |
| topic | transfusion newborn vlbw preterm umbilical cord blood blood storage |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-94547 |
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