| Summary: | 3-(2-hydroxyethyl)-1-(3-aminopropyl)-1H-imidazole-3-ium bromide as an N-heterocyclic carbene salt was synthesized by
the reaction of 3-(1H-imidazole-1-yl
)propane -1-amine with 2-bromoethanol.
The salt can
also be named as imidazole salt which is one of the most stable group of
N-heterocyclic carbenes. The molecular
structure of the product was elucidated by FTIR, 1H NMR, 13C
NMR, GS-MS and elemental analysis. The antimicrobial, antifungal and anticancer
activities of the imidazole salt were also examined. The probit analysis
revealed that IC50 values on HeLa and HepG2 cell lines were 155.955μM and 76.769μM, respectively, at the end of 24
hours treatment. It also was determined that the product has no harmful effect
on healthy mouse
embryonic fibroblasts
(MEF) cells. Significant antimicrobial and antifungal activities of the salt on
Escherichia coli (Migula, 1895) O157:H7 and Listeria
monocytogenes (Pirie, 1940) ATCC 19115 bacteria and the yeast Candida albicans (Berhout,
1923) ATCC
10231 were determined at a concentration value of 32μM.
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