Human milk nutritional composition across lactational stages in Central Africa
The African region encompasses the highest undernutrition burden with the highest neonatal and infant mortality rates globally. Under these circumstances, breastfeeding is one of the most effective ways to ensure child health and development. However, evidence on human milk (HM) composition from Afr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1033005/full |
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| author | Violeta Moya-Alvarez Violeta Moya-Alvarez Simone R. B. M. Eussen Marko Mank Jean-Christophe Junior Koyembi Yawo Tufa Nyasenu Yawo Tufa Nyasenu Gilles Ngaya Daniel Mad-Bondo Jean-Bertrand Kongoma Bernd Stahl Bernd Stahl Philippe J. Sansonetti Philippe J. Sansonetti Raphaëlle Bourdet-Sicard |
| author_facet | Violeta Moya-Alvarez Violeta Moya-Alvarez Simone R. B. M. Eussen Marko Mank Jean-Christophe Junior Koyembi Yawo Tufa Nyasenu Yawo Tufa Nyasenu Gilles Ngaya Daniel Mad-Bondo Jean-Bertrand Kongoma Bernd Stahl Bernd Stahl Philippe J. Sansonetti Philippe J. Sansonetti Raphaëlle Bourdet-Sicard |
| author_sort | Violeta Moya-Alvarez |
| collection | DOAJ |
| description | The African region encompasses the highest undernutrition burden with the highest neonatal and infant mortality rates globally. Under these circumstances, breastfeeding is one of the most effective ways to ensure child health and development. However, evidence on human milk (HM) composition from African women is scarce. This is of special concern, as we have no reference data from HM composition in the context of food insecurity in Africa. Furthermore, data on the evolution of HM across lactational stages in this setting lack as well. In the MITICA study, we conducted a cohort study among 48 Central-African women and their 50 infants to analyze the emergence of gut dysbiosis in infants and describe the mother-infant transmission of microbiota between birth and 6 months of age. In this context, we assessed nutritional components in HM of 48 lactating women in Central Africa through five sampling times from week 1 after birth until week 25. Unexpectedly, HM-type III (Secretor + and Lewis genes -) was predominant in HM from Central African women, and some nutrients differed significantly among HM-types. While lactose concentration increased across lactation periods, fatty acid concentration did not vary significantly. The overall median level of 16 detected individual human milk oligosaccharides (HMOs; core structures as well as fucosylated and sialylated ones) decreased from 7.3 g/l at week 1 to 3.5 g/l at week 25. The median levels of total amino acids in HM dropped from 12.8 mg/ml at week 1 to 7.4 mg/ml at week 25. In contrast, specific free amino acids increased between months 1 and 3 of lactation, e.g., free glutamic acid, glutamine, aspartic acid, and serine. In conclusion, HM-type distribution and certain nutrients differed from Western mother HM. |
| first_indexed | 2024-04-13T10:36:40Z |
| format | Article |
| id | doaj.art-0ee6b77c37514c96b8ae8a1785649f55 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T10:36:40Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-0ee6b77c37514c96b8ae8a1785649f552022-12-22T02:50:02ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.10330051033005Human milk nutritional composition across lactational stages in Central AfricaVioleta Moya-Alvarez0Violeta Moya-Alvarez1Simone R. B. M. Eussen2Marko Mank3Jean-Christophe Junior Koyembi4Yawo Tufa Nyasenu5Yawo Tufa Nyasenu6Gilles Ngaya7Daniel Mad-Bondo8Jean-Bertrand Kongoma9Bernd Stahl10Bernd Stahl11Philippe J. Sansonetti12Philippe J. Sansonetti13Raphaëlle Bourdet-Sicard14Unité de Pathogénie Microbienne Moléculaire, INSERM U1202, Department of Cell Biology and Infection, Institut Pasteur, Paris, FranceEpidemiology of Emergent Diseases Unit, Global Health Department, Institut Pasteur, Paris, FranceHuman Milk Research and Analytical Science, Danone Nutricia Research, Utrecht, NetherlandsHuman Milk Research and Analytical Science, Danone Nutricia Research, Utrecht, NetherlandsUnité d'Epidémiologie, Institut Pasteur de Bangui, Bangui, Central African RepublicLaboratoire d'Analyses Médicales, Institut Pasteur de Bangui, Bangui, Central African RepublicLaboratoire de Biologie Moléculaire et d'Immunologie, Université de Lomé, Lomé, TogoLaboratoire de Biologie Moléculaire et d'Immunologie, Université de Lomé, Lomé, TogoDirection du Service de Santé de la Gendarmerie, Sis Camp Henri Izamo, Bangui, Central African RepublicDirection du Service de Santé de la Gendarmerie, Sis Camp Henri Izamo, Bangui, Central African RepublicHuman Milk Research and Analytical Science, Danone Nutricia Research, Utrecht, NetherlandsDepartment of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, NetherlandsUnité de Pathogénie Microbienne Moléculaire, INSERM U1202, Department of Cell Biology and Infection, Institut Pasteur, Paris, FranceChaire de Microbiologie et Maladies Infectieuses, Collège de France, Paris, France0Health and Nutrition Africa, Danone Nutricia Research, Palaiseau, FranceThe African region encompasses the highest undernutrition burden with the highest neonatal and infant mortality rates globally. Under these circumstances, breastfeeding is one of the most effective ways to ensure child health and development. However, evidence on human milk (HM) composition from African women is scarce. This is of special concern, as we have no reference data from HM composition in the context of food insecurity in Africa. Furthermore, data on the evolution of HM across lactational stages in this setting lack as well. In the MITICA study, we conducted a cohort study among 48 Central-African women and their 50 infants to analyze the emergence of gut dysbiosis in infants and describe the mother-infant transmission of microbiota between birth and 6 months of age. In this context, we assessed nutritional components in HM of 48 lactating women in Central Africa through five sampling times from week 1 after birth until week 25. Unexpectedly, HM-type III (Secretor + and Lewis genes -) was predominant in HM from Central African women, and some nutrients differed significantly among HM-types. While lactose concentration increased across lactation periods, fatty acid concentration did not vary significantly. The overall median level of 16 detected individual human milk oligosaccharides (HMOs; core structures as well as fucosylated and sialylated ones) decreased from 7.3 g/l at week 1 to 3.5 g/l at week 25. The median levels of total amino acids in HM dropped from 12.8 mg/ml at week 1 to 7.4 mg/ml at week 25. In contrast, specific free amino acids increased between months 1 and 3 of lactation, e.g., free glutamic acid, glutamine, aspartic acid, and serine. In conclusion, HM-type distribution and certain nutrients differed from Western mother HM.https://www.frontiersin.org/articles/10.3389/fnut.2022.1033005/fullhuman milkhuman milk oligosaccharides (HMOs)Africafatty acidsamino acids |
| spellingShingle | Violeta Moya-Alvarez Violeta Moya-Alvarez Simone R. B. M. Eussen Marko Mank Jean-Christophe Junior Koyembi Yawo Tufa Nyasenu Yawo Tufa Nyasenu Gilles Ngaya Daniel Mad-Bondo Jean-Bertrand Kongoma Bernd Stahl Bernd Stahl Philippe J. Sansonetti Philippe J. Sansonetti Raphaëlle Bourdet-Sicard Human milk nutritional composition across lactational stages in Central Africa Frontiers in Nutrition human milk human milk oligosaccharides (HMOs) Africa fatty acids amino acids |
| title | Human milk nutritional composition across lactational stages in Central Africa |
| title_full | Human milk nutritional composition across lactational stages in Central Africa |
| title_fullStr | Human milk nutritional composition across lactational stages in Central Africa |
| title_full_unstemmed | Human milk nutritional composition across lactational stages in Central Africa |
| title_short | Human milk nutritional composition across lactational stages in Central Africa |
| title_sort | human milk nutritional composition across lactational stages in central africa |
| topic | human milk human milk oligosaccharides (HMOs) Africa fatty acids amino acids |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1033005/full |
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