Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma
Asthma is a common respiratory disease that affects people of all ages, characterized by considerable heterogeneity in age, clinical presentation, genetics, epigenetics, environmental factors, treatment response, and prognostic outcomes. Asthma affects more than 330 million people worldwide, of whic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Allergies |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-5786/3/2/9 |
| _version_ | 1797596432069296128 |
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| author | Dimitrina Miteva Snezhina Lazova Tsvetelina Velikova |
| author_facet | Dimitrina Miteva Snezhina Lazova Tsvetelina Velikova |
| author_sort | Dimitrina Miteva |
| collection | DOAJ |
| description | Asthma is a common respiratory disease that affects people of all ages, characterized by considerable heterogeneity in age, clinical presentation, genetics, epigenetics, environmental factors, treatment response, and prognostic outcomes. Asthma affects more than 330 million people worldwide, of which 33% are children under 14 years, and 27% are adults whose first symptoms occurred in childhood. However, the genetic and epigenetic mechanisms of childhood allergic diseases and asthma are still not fully understood. Here, we conducted a biomedical narrative review of genes associated with the risk, severity, and susceptibility of childhood asthma since it differs from asthma in adults regarding their pathophysiology, development, and outcomes. We also systematized the available information on epigenetic changes associated with childhood asthma. |
| first_indexed | 2024-03-11T02:51:25Z |
| format | Article |
| id | doaj.art-0ee72309401e4c6d806ef79021ce1c78 |
| institution | Directory Open Access Journal |
| issn | 2313-5786 |
| language | English |
| last_indexed | 2024-03-11T02:51:25Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Allergies |
| spelling | doaj.art-0ee72309401e4c6d806ef79021ce1c782023-11-18T08:57:08ZengMDPI AGAllergies2313-57862023-06-013211513310.3390/allergies3020009Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood AsthmaDimitrina Miteva0Snezhina Lazova1Tsvetelina Velikova2Department of Genetics, Faculty of Biology, Sofia University St. Kliment Ohridski, 8 Dragan Tzankov Str., 1164 Sofia, BulgariaPediatric Department, University Hospital “N. I. Pirogov”, 21 “General Eduard I. Totleben” Blvd, 1606 Sofia, BulgariaMedical Faculty, Sofia University St. Kliment Ohridski, 1 Kozyak Str., 1407 Sofia, BulgariaAsthma is a common respiratory disease that affects people of all ages, characterized by considerable heterogeneity in age, clinical presentation, genetics, epigenetics, environmental factors, treatment response, and prognostic outcomes. Asthma affects more than 330 million people worldwide, of which 33% are children under 14 years, and 27% are adults whose first symptoms occurred in childhood. However, the genetic and epigenetic mechanisms of childhood allergic diseases and asthma are still not fully understood. Here, we conducted a biomedical narrative review of genes associated with the risk, severity, and susceptibility of childhood asthma since it differs from asthma in adults regarding their pathophysiology, development, and outcomes. We also systematized the available information on epigenetic changes associated with childhood asthma.https://www.mdpi.com/2313-5786/3/2/9childhood asthmagenetic factorsepigeneticsGWAS |
| spellingShingle | Dimitrina Miteva Snezhina Lazova Tsvetelina Velikova Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma Allergies childhood asthma genetic factors epigenetics GWAS |
| title | Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma |
| title_full | Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma |
| title_fullStr | Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma |
| title_full_unstemmed | Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma |
| title_short | Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma |
| title_sort | genetic and epigenetic factors in risk and susceptibility for childhood asthma |
| topic | childhood asthma genetic factors epigenetics GWAS |
| url | https://www.mdpi.com/2313-5786/3/2/9 |
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